SCHEMBL5451937

SCHEMBL5451937

CNC(=O)COC(=O)N1CCC(CCc2ccc(Cl)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 1.00
POLB P06746 3/20 0.50
MAOB P27338 1/20 0.47
ALDH1A1 P00352 4/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C19 P33261 1/20 0.43
KDM4E B2RXH2 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
ENPP2 Q13822 5/20 0.42
P2RX3 P56373 1/20 0.41
P2RX2 Q9UBL9 1/20 0.41
LMNA P02545 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5447729 0.93 FAAH (0.88) FAAHPOLBMAOBALDH1A1CYP1A2
SCHEMBL14627810 0.88 FAAH (0.79) FAAHPOLBALDH1A1KDM4ESMN1; SMN2
SCHEMBL5454086 0.87 FAAH (0.77) FAAHSMN1; SMN2ENPP2LMNA
SCHEMBL5450185 0.87 FAAH (0.77) FAAHMAOBALDH1A1KDM4ESMN1; SMN2
SCHEMBL5453621 0.83 FAAH (0.70) FAAHMAOBALDH1A1KDM4ESMN1; SMN2
SCHEMBL2463633 0.82 FAAH (0.69) FAAHPOLBALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL5455256 0.81 FAAH (0.68) FAAHSMN1; SMN2ENPP2LMNA
SCHEMBL5453583 0.81 FAAH (0.67) FAAHMAOBENPP2P2RX3
SCHEMBL5453555 0.80 FAAH (0.66) FAAHMAOBSMN1; SMN2
SCHEMBL20015397 0.80 FAAH (0.66) FAAHMAOBALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109732-A1 LIPID AMINES MODERNATX INC (US) 2026-04-23 US claimed
EP-4376952-A1 ANTI-SIRP-ALPHA ANTIBODIES AND METHODS OF USE THEREOF Alector LLC (US) 2024-06-05 EP claimed
CN-107814161-B Cake assembly line synthesizing equipment 福建省然利食品集团有限公司 2024-04-26 CN claimed
WO-2023010076-A1 ANTI-SIRP-ALPHA ANTIBODIES AND METHODS OF USE THEREOF ALECTOR LLC (US) 2023-02-02 WO claimed
US-20260109732-A1 LIPID AMINES MODERNATX INC (US) 2026-04-23 US disclosed
US-12599600-B2 Compositions and methods for preventing and treating headache through enhancing 2-arachydonyl glyerol activity ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2026-04-14 US disclosed
US-12515253-B2 Compositions, comprising silver nanoplatelets BASF SE (DE) 2026-01-06 US disclosed
EP-4660199-A1 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION Sage Therapeutics, Inc. (US) 2025-12-10 EP disclosed
US-20250235531-A1 MUCOSAL ADMINISTRATION METHODS AND FORMULATIONS MODERNATX, INC. (US) 2025-07-24 US disclosed
US-20250205175-A1 Anti-Aging Composition with mTOR inhibitor for Humans and Other Mammals POSTREL RICHARD (US) 2025-06-26 US disclosed
US-20250152562-A1 Compositions to Enhance and Extend Quality of Life POSTREL RICHARD (US) 2025-05-15 US disclosed
US-12280019-B2 Anti-aging therapy for humans and other mammals POSTREL RICHARD (US) 2025-04-22 US disclosed
US-20220175694-A1 Anti-Aging Therapy for Canines and Other Domesticated Animals POSTREL RICHARD (US) 2022-06-09 US disclosed
EP-3996702-A1 PIEZO AGONISTS FOR PREVENTING OR REVERTING ABNORMAL AMYLOID DEPOSITION Itä-Suomen Yliopisto (FI) 2022-05-18 EP disclosed
US-11331300-B2 Reversing baldness through follicle regeneration POSTREL RICHARD (US) 2022-05-17 US disclosed
US-11318093-B2 Dental topical anesthetic gel PAC-DENT, INC. 2022-05-03 US disclosed
CN-114126617-A Piezoelectric agonists for preventing or reversing abnormal amyloid deposition 东芬兰大学 2022-03-01 CN disclosed
US-11261211-B2 19-NOR neuroactive steroids and methods of use thereof SAGE THERAPEUTICS, INC. (US) 2022-03-01 US disclosed
US-11253594-B2 Drug combinations for protecting against neuronal cell death UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-02-22 US disclosed
US-20070021405-A1 ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021405-A1 ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, HRH2 FAAH 1/4885POLB 2598/4885MAOB 265/4885
US-12599600-B2 Compositions and methods for preventing and treating headache through enhancing 2-arachydonyl glyerol activity FAAH2, PTGS2, PTGES2 FAAH 6/4885POLB 4157/4885MAOB 1333/4885
US-20250235531-A1 MUCOSAL ADMINISTRATION METHODS AND FORMULATIONS MUC1, RNMT, FABP2 FAAH 2174/4885POLB 612/4885MAOB 3505/4885
US-11253594-B2 Drug combinations for protecting against neuronal cell death NLN, CASP3, BAX FAAH 1839/4885POLB 3031/4885MAOB 854/4885
US-11261211-B2 19-NOR neuroactive steroids and methods of use thereof NR3C2, HSD3B1, NR3C1 FAAH 293/4885POLB 3614/4885MAOB 474/4885
US-20260109732-A1 LIPID AMINES LDLR, NPC1, PHOSPHO1 FAAH 886/4885POLB 3025/4885MAOB 1873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.