Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459904 | 0.84 | NPC1 (0.44) | POLBNPC1KDM4ERAB9AHPGD | |
| SCHEMBL5459669 | 0.83 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL5455534 | 0.81 | TUBB4A (0.49) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL27503313 | 0.80 | CYP17A1 (0.60) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL5457794 | 0.77 | POLB (0.55) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL3752648 | 0.76 | KDM4E (0.61) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL8137336 | 0.75 | POLB (0.64) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL12381484 | 0.75 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL5462852 | 0.73 | KDM4E (0.49) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL28395310 | 0.73 | POLB (0.51) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39663-E1 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes | APPLERA CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1196640-B1 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1196640-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | Applera Corporation (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001057264-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6221604-B1 | CONJUGATED TO SUBSTRATES SUCH AS NUCLEOSIDES OR NUCLEOTIDES AND USED AS DETECTION LABELS IN MOLECULAR BIOLOGY EXPERIMENTS; ENERGY TRANSFER DYE | PE CORPORATION | 2001-04-24 | — | — | US | disclosed |