Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.60 |
| ▸ | HPGD | P15428 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | GRK2 | P25098 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183129 | 0.79 | DPP4 (0.50) | ALDH1A1MAPK1TSHRPOLBHTT | |
| Hydrochloric Acid SCHEMBL5467437 | 0.78 | DPP4 (0.45) | ALDH1A1HPGDMAPK1TSHRHTT | |
| SCHEMBL5181969 | 0.78 | DPP4 (0.45) | ALDH1A1HPGDMAPK1TSHRHTT | |
| SCHEMBL637379 | 0.77 | ALDH1A1 (0.61) | ALDH1A1HPGDMAPK1TSHRHSD17B10 | |
| SCHEMBL5458034 | 0.76 | DPP4 (0.69) | ALDH1A1 | |
| SCHEMBL555863 | 0.76 | MAPK1 (0.70) | ALDH1A1HPGDMAPK1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL5471020 | 0.75 | DPP4 (0.68) | ALDH1A1 | |
| SCHEMBL5465205 | 0.75 | DPP4 (0.58) | ALDH1A1TSHRHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL5171044 | 0.74 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPK1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL5466172 | 0.73 | BRAF (0.52) | ALDH1A1HPGDMAPK1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236810-B2 | Substituted 8-aminoalkylthioxanthines, and their use as inhibitors of dipeptidyl peptidase IV | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-08-07 | — | — | US | disclosed |
| US-20070265284-A1 | SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265284-A1 | SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | DPP4, DPP8, DPP7 | ALDH1A1 673/4885HPGD 2404/4885MAPK1 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.