Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457312 | 0.77 | PRMT5 (0.66) | PRMT5KDM4ETLR8POLBCYP1A2 | |
| SCHEMBL5104145 | 0.75 | PRMT5 (1.00) | PRMT5KDM4ETLR8POLBNOD1 | |
| SCHEMBL5448072 | 0.75 | PRMT5 (0.64) | PRMT5KDM4ETLR8POLBCYP1A2 | |
| SCHEMBL5470484 | 0.72 | PRMT5 (0.60) | PRMT5KDM4ETLR8POLBCYP1A2 | |
| SCHEMBL12946292 | 0.72 | CASR (0.43) | PRMT5TLR8LMNACYP1A2FAAH | |
| SCHEMBL5459067 | 0.72 | PRMT5 (0.60) | PRMT5KDM4ETLR8POLBLMNA | |
| SCHEMBL25682015 | 0.71 | PRMT5 (0.58) | PRMT5KDM4ETLR8POLBLMNA | |
| SCHEMBL5141325 | 0.71 | PRMT5 (0.58) | PRMT5KDM4ETLR8POLBCYP1A2 | |
| SCHEMBL5025943 | 0.71 | PRMT5 (0.58) | PRMT5KDM4ETLR8POLBCYP1A2 | |
| SCHEMBL25836331 | 0.71 | CRHR1 (0.31) | PRMT5CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133183-A1 | KRAS INHIBITORS | THERAS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| US-20070232673-A1 | 2-Imino-benzimidazoles | ABBOTT LABORATORIES | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232673-A1 | 2-Imino-benzimidazoles | CYP2C19, UGT2B7, UGT2B17 | PRMT5 2145/4885KDM4E 2704/4885TLR8 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.