Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399117 | 0.84 | ABL1 (0.52) | HSP90AB1ALDH1A1SHMT2KDRABL1 | |
| SCHEMBL3976703 | 0.79 | SELE (0.50) | ALDH1A1SHMT2ABL1CDK8MKNK1 | |
| SCHEMBL3978660 | 0.74 | CAMKK2 (0.47) | HSP90AB1ALDH1A1SHMT2MAP3K8LIMK1 | |
| SCHEMBL29420250 | 0.71 | MAPK1 (0.47) | KDRABL1LIMK1CHEK1AURKA | |
| SCHEMBL6461918 | 0.71 | EGFR (0.49) | KDRABL1LIMK1CHEK1AURKA | |
| SCHEMBL31026187 | 0.71 | EGFR (0.49) | KDRABL1LIMK1CHEK1AURKA | |
| SCHEMBL4801961 | 0.70 | LIMK1 (0.42) | KDRABL1LIMK1CHEK1AURKA | |
| SCHEMBL14375381 | 0.70 | MAPK1 (0.55) | ALDH1A1MAP4K4PIM1FLT3RPS6KA3 | |
| SCHEMBL27084096 | 0.69 | KDM4E (0.41) | ALDH1A1SHMT2MAP3K8AURKADAPK3 | |
| SCHEMBL16363314 | 0.68 | ABL1 (0.60) | SHMT2ABL1FGFR1MKNK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | CXCR4, CXCR1, CXCR3 | HSP90AB1 3621/4885ALDH1A1 683/4885SHMT2 1947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.