Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 20/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 20/20 | 0.70 |
| ▸ | HRH1 | P35367 | 5/20 | 0.62 |
| ▸ | HRH2 | P25021 | 4/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.62 |
| ▸ | HTR1E | P28566 | 3/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | HTR1B | P28222 | 2/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30449380 | 0.90 | TMEM97 (0.77) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL28699149 | 0.90 | TMEM97 (0.77) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL31330699 | 0.87 | NPC1 (0.56) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL23854709 | 0.84 | SIGMAR1 (0.54) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL1842426 | 0.83 | MEN1 (0.61) | CHRM4 | |
| SCHEMBL5458981 | 0.83 | TMEM97 (0.66) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL19521513 | 0.82 | TMEM97 (1.00) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL19521494 | 0.82 | TMEM97 (1.00) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL31173271 | 0.82 | TMEM97 (0.70) | TMEM97SIGMAR1HRH1HRH2HTR2C | |
| SCHEMBL30366420 | 0.81 | NAMPT (0.52) | TMEM97SIGMAR1HRH1HRH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185089-A1 | Benzazepine derivatives for the treatment of neurological and psychiatric disorders | CNR2, GRIN2C, GRIN2B | TMEM97 486/4885SIGMAR1 129/4885HRH1 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.