Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460806 | 0.87 | FABP4 (0.50) | HDAC6HDAC1FABP4FABP5CNR2 | |
| SCHEMBL1867689 | 0.83 | HDAC6 (0.48) | HDAC6HDAC1FABP4FABP5CNR2 | |
| SCHEMBL5448184 | 0.81 | MAPK1 (0.49) | — | |
| SCHEMBL5450508 | 0.79 | FAAH (0.41) | HDAC6HDAC1 | |
| SCHEMBL1872155 | 0.78 | FABP4 (0.39) | HDAC6HDAC1FABP4FABP5SCARB1 | |
| SCHEMBL4250721 | 0.78 | PPARG (0.48) | — | |
| SCHEMBL4248048 | 0.78 | PPARG (0.48) | — | |
| SCHEMBL5450510 | 0.78 | P2RX4 (0.40) | HDAC6HDAC1SIGMAR1 | |
| SCHEMBL5450713 | 0.77 | KDM1A (0.48) | HDAC6SIGMAR1 | |
| SCHEMBL3770886 | 0.77 | NR4A2 (0.42) | HDAC1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | CADILA HEALTHCARE LIMITED (IN) | 2007-05-10 | — | — | US | claimed |
| EP-1709035-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LTD. (IN) | 2006-10-11 | — | — | EP | claimed |
| WO-2005077943-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LIMITED (IN) | 2005-08-25 | — | — | WO | claimed |
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | CADILA HEALTHCARE LIMITED (IN) | 2007-05-10 | — | — | US | disclosed |
| EP-1709035-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LTD. (IN) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005077943-A1 | 1 , 3 - DIOXANE DERIVATIVES AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF I.A. OBESITY AND DIABETES | CADILA HEALTHCARE LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105847-A1 | 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes | GPR119, PPARG, FABP4 | HDAC6 1034/4885HDAC1 479/4885FABP4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.