Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 8/20 | 0.40 |
| ▸ | EHMT1 | Q9H9B1 | 8/20 | 0.40 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453324 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1L3MBTL1POLBMAPK1 | |
| SCHEMBL5457164 | 0.79 | NUDT1 (0.46) | KDM4EALDH1A1L3MBTL1POLBMAPK1 | |
| SCHEMBL5445110 | 0.75 | NUDT1 (0.51) | KDM4EALDH1A1L3MBTL1POLBMAPK1 | |
| SCHEMBL5452783 | 0.75 | NUDT1 (0.51) | KDM4EALDH1A1L3MBTL1PIK3CBPOLB | |
| SCHEMBL5450737 | 0.71 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1POLBMAPK1 | |
| SCHEMBL5452827 | 0.71 | NUDT1 (0.47) | KDM4EALDH1A1L3MBTL1PIK3CBPOLB | |
| SCHEMBL6304381 | 0.66 | BAZ2A (0.39) | KDM4EALDH1A1HTT | |
| SCHEMBL28768632 | 0.66 | MERTK (0.57) | KDM4EFLT3ALDH1A1POLBAXL | |
| SCHEMBL28465573 | 0.66 | EHMT2 (0.41) | EHMT2EHMT1L3MBTL1HTT | |
| SCHEMBL27172361 | 0.65 | MERTK (0.54) | KDM4EALDH1A1POLBAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | KDM4E 521/4885FLT3 58/4885EHMT2 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.