Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | HTR1D | P28221 | 2/20 | 0.66 |
| ▸ | HTR1B | P28222 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 1/20 | 0.66 |
| ▸ | HTR6 | P50406 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HPGDS | O60760 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27829788 | 0.94 | AKR1C3 (0.83) | DRD2DRD3AKR1C3TSHRPOLB | |
| SCHEMBL327835 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8576226 | 0.86 | DRD2 (0.96) | DRD2DRD3HTR1AHTR1DHTR1B | |
| SCHEMBL16026545 | 0.84 | PKM (0.74) | DRD2DRD3AKR1C3TSHRPOLB | |
| SCHEMBL8723365 | 0.84 | TSHR (0.83) | DRD2DRD3HTR1AHTR1DHTR1B | |
| SCHEMBL3904994 | 0.83 | KMT2A (0.68) | DRD2DRD3AKR1C3HTR2ATSHR | |
| SCHEMBL7793932 | 0.83 | AKR1C3 (0.68) | DRD2DRD3AKR1C3TSHRPOLB | |
| SCHEMBL8362372 | 0.82 | TSHR (0.68) | DRD2DRD3AKR1C3TSHRPOLB | |
| SCHEMBL6187316 | 0.82 | DRD2 (0.81) | DRD2DRD3HTR1AHTR1DHTR1B | |
| SCHEMBL1423195 | 0.82 | AKR1C3 (0.66) | DRD2DRD3AKR1C3TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249618-A1 | Novel Piperidine Derivatives as Histamine H3 Receptor Ligands for Treatment of Depression | HRH3, HRH1, HRH4 | DRD2 34/4885DRD3 78/4885AKR1C3 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.