Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266419 | 0.89 | MMP8 (0.74) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL28674585 | 0.87 | MMP8 (0.72) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL31069943 | 0.87 | MMP8 (0.72) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL1275691 | 0.85 | MMP8 (0.70) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL11679477 | 0.85 | KMT2A (0.60) | MMP8MEN1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL28474562 | 0.84 | MMP8 (0.73) | MMP8MEN1NPC1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL10677191 | 0.84 | MMP8 (0.68) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL6959479 | 0.84 | MMP8 (0.68) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL583575 | 0.84 | MMP8 (0.68) | MMP8MEN1NPC1KMT2ACA12 | |
| Ethane SCHEMBL27824026 | 0.84 | MMP8 (0.68) | MMP8MEN1NPC1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015766-A1 | Quinoline Derivatives as NK-3 and NK-2 Antagonists | GlaxoSmithKline S.P.A. & Laboratoire | 2007-01-18 | — | — | US | disclosed |
| US-20040082589-A1 | Quinoline derivatives as nk-3 and nk-2 antagonists | GLAXOSMITHKLINE S.P.A. (IT) | 2004-04-29 | — | — | US | disclosed |
| EP-1334089-A1 | QUINOLINE DERIVATIVES AS NK-3 AND NK-2 ANTAGONISTS | GlaxoSmithKline S.p.A. (IT) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002038547-A1 | QUINOLINE DERIVATIVES AS NK-3 AND NK-2 ANTAGONISTS | GLAXOSMITHKLINE SPA (IT) | 2002-05-16 | — | — | WO | disclosed |
| US-4735959-A | HYPOGLYCEMIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1988-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082589-A1 | Quinoline derivatives as nk-3 and nk-2 antagonists | KCNH3, KCNH2, KCNK3 | MMP8 2613/4885MEN1 3737/4885NPC1 479/4885 |
| US-20070015766-A1 | Quinoline Derivatives as NK-3 and NK-2 Antagonists | KCNK3, KCNQ3, ACKR3 | MMP8 2998/4885MEN1 1861/4885NPC1 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.