Urethane

Urethane

SCHEMBL5458436

CCOC(N)=O.NC(N)=O.O=C(O)O

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Urethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.83
ALDH1A1 P00352 5/20 0.48
LMNA P02545 4/20 0.46
HSD17B10 Q99714 2/20 0.46
GAA P10253 3/20 0.43
MGAM O43451 1/20 0.43
SI P14410 1/20 0.43
MGAM2 Q2M2H8 1/20 0.43
SOAT1 P35610 1/20 0.43
CHRM2 P08172 2/20 0.41
CHRM4 P08173 2/20 0.41
CHRM5 P08912 2/20 0.41
CHRM1 P11229 2/20 0.41
CHRM3 P20309 2/20 0.41
CHRNB2 P17787 2/20 0.41
CHRNA4 P43681 2/20 0.41
HTR1A P08908 1/20 0.41
TSHR P16473 1/20 0.41
CYP2C19 P33261 1/20 0.41
CHRNA7 P36544 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urethane SCHEMBL40457 0.97 ALOX15 (0.88) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL4556053 0.97 ALOX15 (0.88) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL3267746 0.94 ALOX15 (0.83) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL12983702 0.94 ALOX15 (0.83) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL722008 0.94 ALOX15 (0.83) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL6256702 0.94 ALOX15 (0.94) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL32130 0.94 ALOX15 (0.94) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL17373930 0.94 ALOX15 (0.94) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL20210783 0.94 ALOX15 (0.94) ALOX15ALDH1A1LMNAHSD17B10GAA
Urethane SCHEMBL14675738 0.94 ALOX15 (0.94) ALOX15ALDH1A1LMNAHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648106-B2 Artificial tympanic membrane devices and uses MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2023-05-16 US claimed
CN-108699522-B Vascular extracellular matrix hydrogel 高等教育联邦系统-匹兹堡大学 2022-05-27 CN claimed
US-20210000590-A1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES MASSACHUSETTS EYE AND EAR INFIRMARY 2021-01-07 US claimed
WO-2020243832-A1 TISSUE CONSTRUCTS WITH BIOCOMPATIBLE LINEAR SCAFFOLDS, METHODS OF MAKING AND USES THEREOF MCMASTER UNIVERSITY (CA) 2020-12-10 WO claimed
US-10786349-B2 Artificial tympanic membrane devices and uses MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2020-09-29 US claimed
EP-3270821-B1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES MASSACHUSETTS EYE & EAR INFIRMARY (US) 2020-08-19 EP claimed
US-20180042718-A1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2018-02-15 US claimed
EP-3270821-A1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES Massachusetts Eye & Ear Infirmary (US) 2018-01-24 EP claimed
WO-2016154148-A1 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2016-09-29 WO claimed
US-20150132251-A1 Biodegradable Elastomeric Patch for Treating Cardiac or Cardiovascular Conditions UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2015-05-14 US claimed
US-20070056595-A1 Method for treatment of ischaemic tissue MCLACHLAN CRAIG 2007-03-15 US claimed
WO-2004093688-A1 METHOD FOR TREATMENT OF ISCHAEMIC TISSUE MCLACHLAN CRAIG (AU) 2004-11-04 WO claimed
US-12016560-B2 Adjunct materials and methods of using same in surgical methods for tissue sealing CILAG GMBH INTERNATIONAL (CH) 2024-06-25 US disclosed
US-11911034-B2 Adjunct materials and methods of using same in surgical methods for tissue sealing CILAG GMBH INTERNATIONAL (CH) 2024-02-27 US disclosed
EP-2954857-B1 ADJUNCT MATERIALS FOR TISSUE SEALING ETHICON ENDO SURGERY INC (US) 2023-07-19 EP disclosed
US-11648106-B2 Artificial tympanic membrane devices and uses MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2023-05-16 US disclosed
WO-2004093688-A1 METHOD FOR TREATMENT OF ISCHAEMIC TISSUE MCLACHLAN CRAIG (AU) 2004-11-04 WO disclosed
US-6245090-B1 Transcatheter occluding implant SALVIAC LIMITED (IE) 2001-06-12 US disclosed
EP-1028658-A1 IMPLANTABLE OCCLUDER DEVICES FOR MEDICAL USE Salviac Limited (IE) 2000-08-23 EP disclosed
WO-1999023954-A1 IMPLANTABLE OCCLUDER DEVICES FOR MEDICAL USE SALVIAC LIMITED (IE) 1999-05-20 WO disclosed