SCHEMBL5458522

SCHEMBL5458522

CC1=C(C)C(C)C([Si](C)(C)NC(=O)C2CCCCCCCCCCC2)=C1C.[Ti].[Ti].[Ti].[Ti]

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.40
TSHR P16473 3/20 0.39
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 1/20 0.38
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
LMNA P02545 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
P2RX7 Q99572 2/20 0.34
GAA P10253 1/20 0.34
POLB P06746 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8073123 0.85 KMT2A (0.40) RAB9ATSHRKMT2AMEN1SMN1; SMN2
SCHEMBL8218234 0.72 HPGD (0.30) SMN1; SMN2
Hydrochloric Acid SCHEMBL17823015 0.70 HDAC8 (0.37) RAB9ATSHRKMT2AMEN1SMN1; SMN2
SCHEMBL7768024 0.69 HDAC3 (0.33) HDAC8HDAC6
SCHEMBL6438616 0.69
SCHEMBL8168259 0.68 HDAC8 (0.38) RAB9ATSHRKMT2AMEN1SMN1; SMN2
Hydrochloric Acid SCHEMBL2117827 0.68 HDAC8 (0.35) RAB9ATSHRKMT2AMEN1SMN1; SMN2
Hydrochloric Acid SCHEMBL2116438 0.68 HDAC8 (0.35) RAB9ATSHRKMT2AMEN1SMN1; SMN2
SCHEMBL727844 0.67 HDAC8 (0.37) RAB9ATSHRKMT2AMEN1SMN1; SMN2
SCHEMBL7935890 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7169863-B2 Salts of lewis acid/acid adducts and catalyst activators therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2007-01-30 US disclosed
US-7094901-B2 Expanded anionic compounds comprising hydroxyl or quiescent reactive functionality and catalyst activators therefrom DOW GLOBAL MICHIGAN TECHNOLOGIES INC. (US) 2006-08-22 US disclosed
EP-1228109-B1 SUPPORTED CATALYST COMPRISING EXPANDED ANIONS DOW GLOBAL TECHNOLOGIES INC (US) 2006-02-01 EP disclosed
US-20050009688-A1 Expanded anionic compounds comprising hydroxyl or quiescent reactive functionality and catalyst activators therefrom BABB DAVID A (US) 2005-01-13 US disclosed
US-20040162215-A1 Salts of lewis acid/acid adducts and catalyst activators therefrom THE DOW CHEMICAL COMPANY 2004-08-19 US disclosed
EP-1412365-A1 SALT OF LEWIS ACID/ACID ADDUCTS AND CATALYST ACTIVATORS THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2004-04-28 EP disclosed
US-20040077491-A1 Expanded anionic compounds comprising hydroxyl or quiescent reactive functionality and catalyst activators therefrom THE DOW CHEMICAL COMPANY (US) 2004-04-22 US disclosed
US-6716786-B1 LEWIS ACIDS AND BASES THE DOW CHEMICAL COMPANY 2004-04-06 US disclosed
US-6627573-B2 Useful as a cocatalyst for addition coordination polymerization comprising an anion containing at least two Lewis basic sites which are coordinated to Lewis acids, and further containing a hydroxyl group for support attachment THE DOW CHEMICAL COMPANY 2003-09-30 US disclosed
EP-1056752-B1 Catalyst activators comprising expanded anions DOW GLOBAL TECHNOLOGIES INC (US) 2003-06-25 EP disclosed
US-20030032549-A1 Salts of lewis acid/acid adducts and catalyst activators therefrom DOW GLOBAL TECHNOLOGIES INC. 2003-02-13 US disclosed
WO-2003010171-A1 SALT OF LEWIS ACID/ACID ADDUCTS AND CATALYST ACTIVATORS THEREFROM DOW GLOBAL TECHNOLOGIES, INC. (US) 2003-02-06 WO disclosed
US-6462156-B2 AS POLYMERIZATION CATALYST FOR PRODUCING OLEFIN POLYMERS THE DOW CHEMICAL COMPANY 2002-10-08 US disclosed
US-20020032120-A1 Expanded anionic compounds comprising hydroxyl or quiescent reactive functionality and catalyst activators therefrom DOW CHEMICAL COMPANY, THE 2002-03-14 US disclosed
US-20010027161-A1 Catalyst activators comprising expanded anions THE DOW CHEMICAL COMPANY 2001-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030032549-A1 Salts of lewis acid/acid adducts and catalyst activators therefrom SSB, NCF1, CD79B RAB9A 1152/4885TSHR 2471/4885KMT2A 2251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.