Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4588710 | 0.77 | PTPN1 (0.38) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL8469617 | 0.73 | PTPN1 (0.35) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2117827 | 0.71 | HDAC8 (0.35) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2116438 | 0.71 | HDAC8 (0.35) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4458747 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL7788066 | 0.70 | LMNA (0.42) | KMT2AMEN1LMNAP2RX7 | |
| SCHEMBL5458522 | 0.70 | RAB9A (0.40) | HDAC8HDAC6KMT2AMEN1LMNA | |
| SCHEMBL8073123 | 0.69 | KMT2A (0.40) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| SCHEMBL8168259 | 0.69 | HDAC8 (0.38) | HDAC8HDAC6PTPN1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5968826 | 0.69 | HDAC8 (0.35) | HDAC8HDAC6PTPN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111325-B2 | Polymerization processes | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2021-09-07 | — | — | US | claimed |
| WO-2021118715-A1 | LOW AROMATIC POLYOLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2021-06-17 | — | — | WO | claimed |
| US-20210179743-A1 | LOW AROMATIC POLYOLEFINS | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2021-06-17 | — | — | US | claimed |
| EP-3710502-A1 | POLYMERIZATION PROCESSES | ExxonMobil Chemical Patents Inc. (US) | 2020-09-23 | — | — | EP | claimed |
| EP-3704163-A1 | TOLUENE FREE SILICA SUPPORTED SINGLE-SITE METALLOCENE CATALYSTS FROM IN-SITU SUPPORTED ALUMOXANE FORMATION IN ALIPHATIC SOLVENTS | ExxonMobil Chemical Patents Inc. (US) | 2020-09-09 | — | — | EP | claimed |
| EP-3704164-A1 | TOLUENE FREE SILICA SUPPORTED SINGLE-SITE METALLOCENE CATALYSTS FROMIN-SITU | ExxonMobil Chemical Patents Inc. (US) | 2020-09-09 | — | — | EP | claimed |
| US-10717790-B2 | Catalyst composition comprising fluorided support and processes for use thereof | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2020-07-21 | — | — | US | claimed |
| US-10647798-B2 | Spray-dried olefin polymerization catalyst compositions and polymerization processes for using the same | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2020-05-12 | — | — | US | claimed |
| US-10640583-B2 | Catalyst composition comprising fluorided support and processes for use thereof | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2020-05-05 | — | — | US | claimed |
| US-20200071438-A1 | Processes for Preparing a Catalyst System and Polymerizing Olefins | EXXONMOBIL CHEMICAL PATENTS INC (US) | 2020-03-05 | — | — | US | claimed |
| WO-2018118259-A1 | SPRAY-DRIED OLEFIN POLYMERIZATION CATALYST COMPOSITIONS AND POLYMERIZATION PROCESSES FOR USING THE SAME | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2018-06-28 | — | — | WO | claimed |
| US-20180171040-A1 | Catalyst Composition Comprising Fluorided Support and Processes for Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-06-21 | — | — | US | claimed |
| WO-2018075245-A1 | MIXED CATALYST SYSTEMS AND METHODS OF USING THE SAME | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2018-04-26 | — | — | WO | claimed |
| US-20180072823-A1 | Catalyst Composition Comprising Fluorided Support and Processes for Use Thereof | EXXONMOBIL CHEMICAL PATENTS INC. | 2018-03-15 | — | — | US | claimed |
| EP-3286231-A1 | CATALYST COMPOSITION COMPRISING FLUORIDED SUPPORT AND PROCESSES FOR USE THEREOF | ExxonMobil Chemical Patents Inc. (US) | 2018-02-28 | — | — | EP | claimed |
| EP-3274380-A1 | CATALYST COMPOSITION COMPRISING FLUORIDED SUPPORT AND PROCESSES FOR USE THEREOF | ExxonMobil Chemical Patents Inc. (US) | 2018-01-31 | — | — | EP | claimed |
| US-20170327604-A1 | OLEFIN POLYMERIZATION CATALYST SYSTEM COMPRISING MESOPOROUS ORGANOSILICA SUPPORT | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY | 2017-11-16 | — | — | US | claimed |
| WO-2016171807-A1 | CATALYST COMPOSITION COMPRISING FLUORIDED SUPPORT AND PROCESSES FOR USE THEREOF | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2016-10-27 | — | — | WO | claimed |
| WO-2016171808-A1 | CATALYST COMPOSITION COMPRISING FLUORIDED SUPPORT AND PROCESSES FOR USE THEREOF | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2016-10-27 | — | — | WO | claimed |
| WO-2016094843-A2 | OLEFIN POLYMERIZATION CATALYST SYSTEM COMPRISING MESOPOROUS ORGANOSILICA SUPPORT | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2016-06-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327604-A1 | OLEFIN POLYMERIZATION CATALYST SYSTEM COMPRISING MESOPOROUS ORGANOSILICA SUPPORT | SIK1, SIK2, SPIN1 | HDAC8 3935/4885HDAC6 2506/4885PTPN1 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.