Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317679 | 0.88 | MAPT (0.65) | EPHX2TP53BP1POLBALDH1A1NAMPT | |
| SCHEMBL5466382 | 0.86 | EPHX2 (0.70) | EPHX2HRH3ALDH1A1NAMPTSMN1; SMN2 | |
| SCHEMBL14430802 | 0.85 | RAF1 (0.61) | EPHX2HRH3DRD2ADRA1ADRD3 | |
| SCHEMBL14430782 | 0.85 | LTA4H (0.59) | EPHX2HRH3POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL14430729 | 0.83 | KMT2A (0.54) | EPHX2HRH3ALDH1A1NAMPTSMN1; SMN2 | |
| SCHEMBL3072529 | 0.83 | HRH3 (0.55) | EPHX2HRH3POLBSMN1; SMN2HPGD | |
| SCHEMBL5481576 | 0.83 | NAMPT (0.61) | EPHX2POLBNAMPTDRD2HPGD | |
| SCHEMBL29658300 | 0.82 | POLB (0.64) | EPHX2TP53BP1HRH3POLBALDH1A1 | |
| SCHEMBL18507055 | 0.82 | HRH3 (0.59) | EPHX2HRH3POLBNAMPTSMN1; SMN2 | |
| SCHEMBL5474859 | 0.81 | MEN1 (0.61) | HRH3POLBALDH1A1NAMPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | EPHX2 3018/4885TP53BP1 4449/4885HRH3 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.