Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11708856 | 0.83 | HTT (0.56) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10992973 | 0.81 | HMGCR (0.51) | LMNAMAPK1SMN1; SMN2HTTPDE4D | |
| SCHEMBL25236549 | 0.80 | MAPT (0.51) | LMNAMAPK1PDE4DALDH1A1CYP1A2 | |
| SCHEMBL4255074 | 0.78 | PDE4D (0.53) | LMNAMAPK1SMN1; SMN2PDE4DALDH1A1 | |
| SCHEMBL7496866 | 0.77 | MAPT (0.46) | LMNAMAPK1SMN1; SMN2HTTPDE4D | |
| SCHEMBL11427275 | 0.76 | MAPT (0.48) | LMNAMAPK1SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL27042972 | 0.76 | ALDH1A1 (0.33) | LMNAHTTALDH1A1HSD17B10MEN1 | |
| SCHEMBL31021034 | 0.75 | FLT1 (0.49) | LMNAMAPK1ALDH1A1CYP1A2MEN1 | |
| SCHEMBL982498 | 0.75 | RAB9A (0.62) | LMNASMN1; SMN2HTTALDH1A1MEN1 | |
| SCHEMBL4745099 | 0.75 | LMNA (0.47) | LMNAMAPK1SMN1; SMN2HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249616-A1 | Substituted 1-Benzyl-4-Substituted Piperazine Analogues | NEUROGEN CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| US-7253168-B2 | Substituted 1-benzyl-4-substituted piperazine analogues | NEUROGEN CORPORATION (US) | 2007-08-07 | — | — | US | disclosed |
| US-20060142301-A1 | Substituted 1-benzyl-4-substituted piperazine analogues | NEUROGEN CORPORATION | 2006-06-29 | — | — | US | disclosed |
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | NEUROGEN CORPORATION | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249616-A1 | Substituted 1-Benzyl-4-Substituted Piperazine Analogues | MCHR1, MCHR2, PRLHR | LMNA 3670/4885MAPK1 2880/4885SMN1; SMN2 654/4885 |
| US-20060009456-A1 | Aryl-substituted piperazine derivatives | MCHR1, MCHR2, PRLHR | LMNA 4065/4885MAPK1 3869/4885SMN1; SMN2 1196/4885 |
| US-20060142301-A1 | Substituted 1-benzyl-4-substituted piperazine analogues | MCHR1, MCHR2, PRLHR | LMNA 3670/4885MAPK1 2880/4885SMN1; SMN2 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.