Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10464245 | 0.88 | HTR1A (0.52) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL18153040 | 0.88 | CA9 (0.51) | CRBNSMYD3HDAC6NPC1MAPT | |
| SCHEMBL4304359 | 0.86 | EPHX2 (0.62) | SMYD3GRIN2BHTR1AHTR2AHTR7 | |
| SCHEMBL10461840 | 0.86 | HTR7 (0.55) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL7341659 | 0.85 | SMYD3 (0.54) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL2641171 | 0.85 | CRBN (0.51) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL2641172 | 0.85 | CRBN (0.51) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL1145012 | 0.85 | ALDH1A1 (0.55) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL1198034 | 0.85 | CRBN (0.51) | CRBNSMYD3HDAC3HDAC4HDAC1 | |
| SCHEMBL10463736 | 0.85 | HTR1A (0.54) | CRBNSMYD3HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286966-B1 | 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINE | SOD CONSEILS RECH APPLIC (FR) | 2008-07-16 | — | — | EP | disclosed |
| US-20070185168-A1 | Piperidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-08-09 | — | — | US | disclosed |
| EP-1736474-A1 | PIPERIDINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-12-27 | — | — | EP | disclosed |
| US-4921862-A | Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1990-05-01 | — | — | US | disclosed |
| US-4792561-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185168-A1 | Piperidine derivatives | GRIN2C, GRIN1, GRIN3A | CRBN 919/4885SMYD3 1635/4885HDAC3 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.