Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL10678990 | 1.00 | NAPRT (0.53) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Benzene SCHEMBL27460903 | 1.00 | NAPRT (0.53) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL28192777 | 1.00 | NAPRT (0.53) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL28275562 | 0.97 | NAPRT (0.50) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL8371169 | 0.97 | NAPRT (0.50) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL28751369 | 0.97 | NAPRT (0.50) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL28392625 | 0.95 | NAPRT (0.47) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL29135433 | 0.90 | TDP1 (0.43) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL9258140 | 0.90 | TDP1 (0.43) | NAPRTTDP1TSHRLMNAALDH1A1 | |
| Pyridine SCHEMBL20972307 | 0.88 | NAPRT (0.53) | NAPRTTDP1TSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 314 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119504378-A | Method for preparing p- (1-ethoxyethoxy) styrene | 贵港市微芯科技有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-118930474-A | Preparation method of key intermediate of ulcerative colitis treatment drug | 北京康立生医药技术开发有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-118851982-A | Preparation method of itramod key intermediate | 北京康立生医药技术开发有限公司 | 2024-10-29 | — | — | CN | claimed |
| CN-118745126-A | Synthesis method of p-chloromethyl styrene | 北京联本医药化学技术有限公司 | 2024-10-08 | — | — | CN | claimed |
| CN-118546265-A | Cellulose aldehyde and preparation method and application thereof | 新疆农业大学 | 2024-08-27 | — | — | CN | claimed |
| CN-115974659-B | Synthesis method of 1- (1-ethoxyethoxy) -4-vinylbenzene | 徐州博康信息化学品有限公司 | 2024-08-09 | — | — | CN | claimed |
| CN-117702170-A | Preparation method for constructing atomic-level tungsten-based energy storage/electrocatalytic material with assistance of ionic liquid | 江苏大学 | 2024-03-15 | — | — | CN | claimed |
| CN-117285542-A | Preparation method of balo Sha Weizhi and key intermediate thereof | 广西天铭药业有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-117209499-A | Preparation method of ertapenem amide and application of ertapenem amide in preparation quality research | 重庆圣华曦药业股份有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-113880689-B | Preparation method of 3-methyl-1, 5-pentanediol | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| EP-0915092-A1 | Process for the preparation of 6-(arylcarbonyl)-4-oximo-dihydrobenzothiopyran herbicides and intermediates useful therein | American Cyanamid Company (US) | 1999-05-12 | — | — | EP | claimed |
| EP-0577302-B1 | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates | LILLY CO ELI (US) | 1997-07-16 | — | — | EP | claimed |
| EP-0640614-B1 | Stereoselective process for preparing beta-anomer enriched 2-deoxy-2, 2-difluoro-d-ribofuranosyl-3, 5-hydroxy protected-1-alkyl and aryl sulfonate intermediates | LILLY CO ELI (US) | 1996-12-04 | — | — | EP | claimed |
| US-5424416-A | Sulfonating a lactol, followed with nucleobase anion, forming anomers | ELI LILLY AND COMPANY (US) | 1995-06-13 | — | — | US | claimed |
| EP-0640614-A2 | Stereoselective process for preparing beta-anomer enriched 2-deoxy-2, 2-difluoro-d-ribofuranosyl-3, 5-hydroxy protected-1-alkyl and aryl sulfonate intermediates | ELI LILLY AND COMPANY (US) | 1995-03-01 | — | — | EP | claimed |
| EP-0577302-A1 | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates | ELI LILLY AND COMPANY (US) | 1994-01-05 | — | — | EP | claimed |
| US-5256798-A | Treating beta-anomer ribofuranosyl sulfonate with source of conjugate anion | ELI LILLY AND COMPANY (US) | 1993-10-26 | — | — | US | claimed |
| US-4845219-A | ANTITUMOR, ANTOCOAGULANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-04 | — | — | US | claimed |
| EP-0255366-A2 | Nitrogen- and sulfur-containing lipid compound, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-02-03 | — | — | EP | claimed |
| US-4448779-A | 5-O-CYANOBENZYL-4,5,6,7-TETRAHYDROTHIENO(3,2-C)PYRIDINE | SANOFI (FR) | 1984-05-15 | — | — | US | claimed |