SCHEMBL546445

SCHEMBL546445

Cc1cccc2oc(=O)ccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.59
ALDH1A1 P00352 6/20 0.47
LMNA P02545 4/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CA12 O43570 4/20 0.47
CA9 Q16790 4/20 0.47
CA1 P00915 3/20 0.47
MCL1 Q07820 2/20 0.47
CA2 P00918 1/20 0.47
CA3 P07451 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47
SOST Q9BQB4 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CA14 Q9ULX7 1/20 0.47
CA5B Q9Y2D0 1/20 0.47
CYP3A4 P08684 2/20 0.46
MAOA P21397 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5542888 0.77 CYP2A6 (0.56) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL6560665 0.76 CYP2A6 (0.60) CYP2A6LMNACA12CA9CA1
SCHEMBL15842641 0.76 CYP2A6 (0.56) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL11035090 0.75 CYP2A6 (0.55) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL450134 0.75 CA12 (0.60) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL11034294 0.75 CYP2A6 (0.55) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL66891 0.75 MAOA (0.74) ALDH1A1LMNASMN1; SMN2CA12CA9
SCHEMBL8252613 0.75 CYP2A6 (0.55) CYP2A6ALDH1A1LMNASMN1; SMN2CA12
SCHEMBL29474940 0.75 MAOA (0.74) ALDH1A1LMNASMN1; SMN2CA12CA9
SCHEMBL2670683 0.75 NQO1 (0.62) CYP2A6ALDH1A1LMNASMN1; SMN2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195435-B2 5-methylchromone and the preparation method and application thereof HAINAN MEDICAL UNIVERSITY (CN) 2025-01-14 US claimed
CN-112174922-B 5-methyl primary ketone and preparation method and application thereof 海南医学院 2023-07-11 CN claimed
CN-113527244-B 5-methyl chromone derivative and synthetic method and application thereof 海南医学院 2023-02-03 CN claimed
US-20220324824-A1 A 5-METHYLCHROMONE AND THE PREPARATION METHOD AND APPLICATION THEREOF HAINAN MEDICAL UNIVERSITY (CN) 2022-10-13 US claimed
CN-113527244-A 5-methyl chromone derivative and synthetic method and application thereof 海南医学院 2021-10-22 CN claimed
CN-112174922-A 5-methyl chromone and preparation method and application thereof 海南医学院 2021-01-05 CN claimed
US-9127092-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2015-09-08 US claimed
US-20140187725-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2014-07-03 US claimed
US-5639893-A Process for producing octahydrocoumarins and same as a product of such process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-06-17 US claimed
EP-0757989-A1 A process for producing octahydrocoumarins and same as a product of such process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-02-12 EP claimed
CN-1119188-A 4-phenoxycoumarins as herbicidal agents AMERICAN CYANAMID CO (US) 1996-03-27 CN claimed
US-12195435-B2 5-methylchromone and the preparation method and application thereof HAINAN MEDICAL UNIVERSITY (CN) 2025-01-14 US disclosed
US-12195435-B2 5-methylchromone and the preparation method and application thereof HAINAN MEDICAL UNIVERSITY (CN) 2025-01-14 US disclosed
US-12195435-B2 5-methylchromone and the preparation method and application thereof HAINAN MEDICAL UNIVERSITY (CN) 2025-01-14 US disclosed
US-11857657-B2 Diarylalkanes as potent inhibitors of binuclear enzymes UNIGEN, INC. (US) 2024-01-02 US disclosed
US-5639893-A Process for producing octahydrocoumarins and same as a product of such process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-06-17 US disclosed
EP-0757989-A1 A process for producing octahydrocoumarins and same as a product of such process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-02-12 EP disclosed
WO-1996025937-A1 CINNAMOYL-C-GLYCOSIDE CHROMONE ISOLATED FROM ALOE BARBADENSIS UNIVERA PHARMACEUTICALS, INC. (US) 1996-08-29 WO disclosed
EP-0672664-A1 Little spheres of coumarin and/or derivatives and their process for preparation RHONE-POULENC CHIMIE (FR) 1995-09-20 EP disclosed
US-4441969-A ARYL HYDROXY CARBOXYLIC ACID OMI INTERNATIONAL CORPORATION (US) 1984-04-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195435-B2 5-methylchromone and the preparation method and application thereof TYR, DHCR7, CYP46A1 CYP2A6 58/4885ALDH1A1 258/4885LMNA 832/4885
US-20220324824-A1 A 5-METHYLCHROMONE AND THE PREPARATION METHOD AND APPLICATION THEREOF TYR, DHCR7, CYP51A1 CYP2A6 58/4885ALDH1A1 313/4885LMNA 898/4885
US-11857657-B2 Diarylalkanes as potent inhibitors of binuclear enzymes TYR, DDT, HAAO CYP2A6 356/4885ALDH1A1 953/4885LMNA 2746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.