Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666712 | 0.85 | NPC1 (0.48) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL5457165 | 0.82 | ALDH1A1 (0.44) | KDM4EHKDC1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL5459715 | 0.81 | ALDH1A1 (0.43) | KDM4EHKDC1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL2666711 | 0.79 | ALDH1A1 (0.45) | KDM4EHKDC1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL2643297 | 0.79 | PRKAA2 (0.40) | KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL2666573 | 0.78 | ALDH1A1 (0.45) | KDM4EHKDC1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL2666548 | 0.75 | LMNA (0.55) | KDM4EALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL2666614 | 0.74 | POLB (0.48) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2656449 | 0.74 | TSHR (0.38) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2666710 | 0.74 | MAPK1 (0.40) | KDM4EALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117808-A1 | Substituted Cycloalkylpyrrolones As Allosteric Modulators Of Glucokinase | GCKR, GCK, GALK1 | AHR 3250/4885KDM4E 1627/4885HKDC1 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.