Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765999 | 0.84 | NFKB1 (0.70) | IAPPNFKB1JUNNFE2L2CA1 | |
| SCHEMBL29625452 | 0.84 | NFKB1 (0.70) | IAPPNFKB1JUNNFE2L2CA1 | |
| SCHEMBL8687395 | 0.84 | NFKB1 (0.70) | IAPPNFKB1JUNNFE2L2CA1 | |
| SCHEMBL766000 | 0.84 | NFKB1 (0.70) | IAPPNFKB1JUNNFE2L2CA1 | |
| SCHEMBL1608290 | 0.84 | NFKB1 (0.70) | IAPPNFKB1JUNNFE2L2CA1 | |
| SCHEMBL5595089 | 0.83 | IAPP (0.47) | IAPPBACE1NFKB1ALOX5JUN | |
| SCHEMBL31256670 | 0.82 | NFKB1 (0.71) | IAPPBACE1ERN1NFKB1ALOX5 | |
| SCHEMBL31083592 | 0.82 | NFKB1 (0.71) | IAPPBACE1ERN1NFKB1ALOX5 | |
| SCHEMBL89185 | 0.82 | NFKB1 (0.71) | IAPPBACE1ERN1NFKB1ALOX5 | |
| SCHEMBL307296 | 0.82 | NFKB1 (0.71) | IAPPBACE1ERN1NFKB1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132000-B2 | Agents for oxidatively dying keratin fibers | WELLA AG (DE) | 2006-11-07 | — | — | US | claimed |
| EP-1499281-A1 | AGENTS FOR OXIDATIVELY DYING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2005-01-26 | — | — | EP | claimed |
| US-20040187226-A1 | Agents for oxidatively dying keratin fibers | Wella GmbH (DE) | 2004-09-30 | — | — | US | claimed |
| WO-2003090700-A1 | AGENTS FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2003-11-06 | — | — | WO | claimed |
| US-20070006395-A1 | Agents containing 4-(2-hydroxyethyl)amino-3-nitro-1-benzotrifluoride for dyeing keratin fibers | WELLA AG (DE) | 2007-01-11 | — | — | US | disclosed |
| EP-1720946-A1 | AGENTS CONTAINING 4-(2-HYDROXYETHYL)AMINO-3-NITRO-1-BENZOTRIFLUORIDE FOR DYEING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2006-11-15 | — | — | EP | disclosed |
| US-7132000-B2 | Agents for oxidatively dying keratin fibers | WELLA AG (DE) | 2006-11-07 | — | — | US | disclosed |
| WO-2005072688-A1 | AGENTS CONTAINING 4-(2-HYDROXYETHYL)AMINO-3-NITRO-1-BENZOTRIFLUORIDE FOR DYEING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2005-08-11 | — | — | WO | disclosed |
| US-6852310-B2 | Skin lightening agents, compositions and methods | UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1499281-A1 | AGENTS FOR OXIDATIVELY DYING KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-20040187226-A1 | Agents for oxidatively dying keratin fibers | Wella GmbH (DE) | 2004-09-30 | — | — | US | disclosed |
| US-20040042983-A1 | Skin lightening agents, compositions and methods | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003090700-A1 | AGENTS FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040042983-A1 | Skin lightening agents, compositions and methods | AOC3, TYR, CYP8B1 | IAPP 4879/4885BACE1 3244/4885ERN1 3665/4885 |
| US-20040187226-A1 | Agents for oxidatively dying keratin fibers | KRT18, GPX1, CBR1 | IAPP 2461/4885BACE1 3110/4885ERN1 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.