Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.48 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187946 | 0.93 | ESR2 (0.53) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL1188497 | 0.93 | ESR2 (0.60) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL1188325 | 0.92 | NPC1 (0.61) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL5460878 | 0.86 | NPC1 (0.62) | ESR2NR1H2NPC1RAB9AMAPT | |
| SCHEMBL1187860 | 0.86 | ESR2 (0.62) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL1188540 | 0.86 | ESR2 (0.62) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL5452223 | 0.86 | TMPRSS2 (0.55) | ESR2NPC1RAB9ATMPRSS2MAPT | |
| SCHEMBL1188220 | 0.86 | ESR2 (0.52) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL1187942 | 0.85 | ESR2 (0.58) | ESR2NR1H2NPC1RAB9ATMPRSS2 | |
| SCHEMBL1188437 | 0.85 | ESR2 (0.61) | ESR2NR1H2NPC1RAB9ATMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | ESR2 3787/4885NR1H2 1573/4885NPC1 1089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.