Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 1.00 |
| ▸ | HTR3A | P46098 | 3/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.65 |
| ▸ | HTR6 | P50406 | 2/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.65 |
| ▸ | HTR3B | O95264 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547174 | 0.87 | HTR1A (0.77) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL546374 | 0.87 | HTR1A (0.77) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL11508466 | 0.84 | SLC6A2 (0.72) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL5335460 | 0.84 | HTR1A (0.71) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL546981 | 0.84 | HTR1A (0.71) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL547695 | 0.84 | HTR1A (0.71) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL547169 | 0.84 | HTR1A (0.71) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL11498523 | 0.82 | SLC6A2 (0.70) | HTR1ASLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL11545675 | 0.82 | SLC6A2 (0.68) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A | |
| SCHEMBL4322392 | 0.81 | HTR1A (0.68) | HTR1ASLC6A2SLC6A4SLC6A3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112831206-B | Inorganic oxide dispersion with controllable water content and preparation method thereof | 凯斯科技股份有限公司 | 2022-12-30 | — | — | CN | claimed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | claimed |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2007-03-15 | — | — | US | claimed |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2005-01-20 | — | — | US | claimed |
| CN-1561336-A | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | LUNDBECK & CO AS H (DK) | 2005-01-05 | — | — | CN | claimed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | claimed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | claimed |
| CN-112831206-B | Inorganic oxide dispersion with controllable water content and preparation method thereof | 凯斯科技股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-20220047582-A1 | PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE | SRX CARDIO, LLC | 2022-02-17 | — | — | US | disclosed |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2021-09-09 | — | — | US | disclosed |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2020-11-24 | — | — | US | disclosed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | disclosed |
| US-9708280-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2017-07-18 | — | — | US | disclosed |
| CN-1145620-A | New piperazine derivatives and its prepn. | SAMJIN PHARM CO LTD (KR) | 1997-03-19 | — | — | CN | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |
| EP-0749425-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARM. CO., LTD. (KR) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996021648-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1996-07-18 | — | — | WO | disclosed |
| US-4328223-A | 2-Amino-3a,4,5,6-tetrahydro-perimidine derivatives and their medicinal use in combatting circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | disclosed |
| EP-0004904-A1 | 2-Amino-3a,4,5,6-tetrahydroperimidine derivatives, medicaments containing them and process for their preparation | BAYER AG (DE) | 1979-10-31 | — | — | EP | disclosed |
| US-4064245-A | N-Phenoxyphenyl-piperazines | SCIENCE UNION ET CIE, SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1977-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885SLC6A2 21/4885SLC6A4 7/4885 |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885SLC6A2 21/4885SLC6A4 7/4885 |
| US-20220047582-A1 | PHENYLPIPERAZINE PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) MODULATORS AND THEIR USE | PCSK9, LDLR, PCSK7 | HTR1A 1740/4885SLC6A2 4641/4885SLC6A4 4548/4885 |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885SLC6A2 21/4885SLC6A4 7/4885 |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | HTR1A 5/4885SLC6A2 21/4885SLC6A4 7/4885 |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885SLC6A2 21/4885SLC6A4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.