Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1990900 | 0.85 | PDE10A (0.56) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL5467728 | 0.79 | SOS1 (0.46) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL27662448 | 0.79 | ACHE (0.41) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL27642139 | 0.79 | ACHE (0.41) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL27841270 | 0.77 | MAPT (0.43) | TDP1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL17997972 | 0.76 | PDE10A (0.73) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL8402283 | 0.76 | ALDH1A1 (0.50) | PDE10AALDH1A1TDP1POLBRAB9A | |
| SCHEMBL30535903 | 0.75 | ALDH1A1 (0.74) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL1287837 | 0.75 | ALDH1A1 (0.74) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| SCHEMBL29029891 | 0.75 | SOS1 (0.54) | ALDH1A1TDP1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | IDO1, IDO2, TPH1 | PDE10A 352/4885ALDH1A1 477/4885TDP1 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.