SCHEMBL5469255

SCHEMBL5469255

CC[C@H]1C(=O)N(c2ccc3c(c2)CCN(C)CC3)C[C@@H]1NC(=O)c1ccc(Br)s1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.43
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
POLB P06746 1/20 0.40
NFKB1 P19838 1/20 0.40
CASP3 P42574 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SENP8 Q96LD8 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
USP2 O75604 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5464399 0.93 F10 (0.40) F10MEN1KMT2ANPC1RAB9A
SCHEMBL5472123 0.92 F10 (0.40) F10MEN1KMT2ANPC1RAB9A
SCHEMBL5474672 0.89 F10 (0.47) F10KMT2AF2
SCHEMBL5475952 0.82 F10 (0.45) F10KMT2AF2
SCHEMBL5472527 0.81 F10 (0.45) F10KMT2AF2
SCHEMBL5472479 0.80 TP53 (0.47) F10MEN1KMT2ANPC1RAB9A
SCHEMBL5470291 0.79 F10 (0.44) F10KMT2AF2
SCHEMBL14582532 0.79 F10 (0.44) F10KMT2AF2
SCHEMBL5469249 0.78 F10 (0.43) F10KMT2AF2
SCHEMBL14582534 0.78 F10 (0.43) F10KMT2AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070032473-A1 Substituted amides and their use as medicaments GERLACH KAI 2007-02-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032473-A1 Substituted amides and their use as medicaments OAT, HLA-B, BCAT2 F10 1757/4885MEN1 1994/4885KMT2A 2086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.