Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5461970 | 0.86 | KCNH2 (0.66) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL5456650 | 0.83 | OPRM1 (0.70) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL4698472 | 0.80 | OPRM1 (0.72) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL6055586 | 0.79 | KCNH2 (0.66) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL5608182 | 0.79 | KCNH2 (1.00) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL4757382 | 0.79 | OPRM1 (0.50) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL4756157 | 0.75 | OPRM1 (0.49) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL5851614 | 0.73 | OPRM1 (0.68) | KCNH2OPRM1OPRK1OPRD1 | |
| SCHEMBL4703423 | 0.71 | OPRM1 (0.54) | OPRM1OPRK1OPRD1 | |
| SCHEMBL4697637 | 0.70 | OPRM1 (0.71) | KCNH2OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030087898-A1 | 3-azabicyclo[3.1.0]hexane derivatives | PFIZER INC. | 2003-05-08 | — | — | US | claimed |
| US-20070054950-A1 | 3-Azabicyclo[3.1.0]hexane derivatives | PFIZER INC. | 2007-03-08 | — | — | US | disclosed |
| US-7153976-B2 | Purification process for an azabicyclo[3.1.0]hexane compound | PFIZER INC. (US) | 2006-12-26 | — | — | US | disclosed |
| EP-1678136-A1 | PROCESS FOR PREPARING AN AZABICYCLO[3.1.0]HEXANE COMPOUND | Pfizer Products Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| US-7049335-B2 | 3-azabicyclo[3.1.0]hexane derivatives | PFIZER INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20050171178-A1 | 3-Azabicyclo[3.1.0]hexane derivatives | PFIZER INC | 2005-08-04 | — | — | US | disclosed |
| WO-2005033080-A1 | PROCESS FOR PREPARING AN AZABICYCLO[3.1.0]HEXANE COMPOUND | PFIZER PRODUCTS INC. (US) | 2005-04-14 | — | — | WO | disclosed |
| US-20050075387-A1 | Process for preparing an azabicyclo[3.1.0] hexane compound | PFIZER INC | 2005-04-07 | — | — | US | disclosed |
| EP-1440059-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2004-07-28 | — | — | EP | disclosed |
| US-20030087898-A1 | 3-azabicyclo[3.1.0]hexane derivatives | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| WO-2003035622-A1 | 3-AZABICYCLO (3.1.0) HEXANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087898-A1 | 3-azabicyclo[3.1.0]hexane derivatives | OPRD1, OPRM1, OPRK1 | KCNH2 542/4885OPRM1 2/4885OPRK1 3/4885 |
| US-20050171178-A1 | 3-Azabicyclo[3.1.0]hexane derivatives | OPRD1, OPRM1, OPRK1 | KCNH2 561/4885OPRM1 2/4885OPRK1 3/4885 |
| US-20070054950-A1 | 3-Azabicyclo[3.1.0]hexane derivatives | OPRD1, OPRM1, OPRK1 | KCNH2 546/4885OPRM1 2/4885OPRK1 3/4885 |
| US-20050075387-A1 | Process for preparing an azabicyclo[3.1.0] hexane compound | AZI2, CYP1B1, CYP4B1 | KCNH2 1517/4885OPRM1 2847/4885OPRK1 3668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.