Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420807 | 1.00 | CES2 (0.50) | CES2CES1MAPTCYP1A2HPGD | |
| Chlorobenzene SCHEMBL28198788 | 0.86 | MAOB (0.51) | CES2CES1MAPTCYP1A2TSHR | |
| SCHEMBL4452292 | 0.80 | ALDH5A1 (0.56) | CES2MAPTHPGDCYP1B1CA1 | |
| SCHEMBL9056522 | 0.80 | ALDH5A1 (0.56) | CES2MAPTHPGDCYP1B1CA1 | |
| SCHEMBL14842660 | 0.78 | TPMT (0.48) | CYP1A2HPGDCA1CA2CXCL12 | |
| SCHEMBL1193448 | 0.78 | MEN1 (0.53) | CES2CES1MAPTCYP1A2CYP2C19 | |
| SCHEMBL4862884 | 0.78 | CES2 (0.50) | CES2CES1MAPTCYP1A2ALOX12 | |
| SCHEMBL12997454 | 0.78 | MEN1 (0.53) | CES2CES1MAPTCYP1A2CYP2C19 | |
| SCHEMBL11490236 | 0.78 | MEN1 (0.53) | CES2CES1MAPTCYP1A2CYP2C19 | |
| SCHEMBL14842658 | 0.78 | TPMT (0.48) | CYP1A2HPGDCA1CA2CXCL12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673092-B1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA IP NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | 4 AZA BIOSCIENCE NV (BE) | 2007-02-08 | — | — | US | disclosed |
| EP-1673092-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA Bioscience nv (BE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005039587-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA BIOSCIENCE NV (BE) | 2005-05-06 | — | — | WO | disclosed |
| EP-0944576-A1 | STROBILURINE ANALOGUE COMPOUNDS WITH FUNGICIDAL ACTIVITY | ISAGRO RICERCA S.r.l. (IT) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998021174-A1 | STROBILURINE ANALOGUE COMPOUNDS WITH FUNGICIDAL ACTIVITY | ISAGRO RICERCA S.R.L. (IT) | 1998-05-22 | — | — | WO | disclosed |
| WO-1997021711-A1 | PROCESS FOR PREPARING 4-AMINOPTERIDINE DERIVATIVES | LONZA AG (CH) | 1997-06-19 | — | — | WO | disclosed |
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4217449-A | Process for the preparation of bis-triazolylstilbenes | BAYER AKTIENGESELLSCHAFT (DE) | 1980-08-12 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032477-A1 | Pteridine derivatives useful for making pharmaceutical compositions | TPMT, TYMS, TNF | CES2 4513/4885CES1 1984/4885MAPT 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.