Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866530 | 0.86 | HPGD (0.55) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL14995943 | 0.84 | TUBB4A (0.41) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL30866418 | 0.83 | POLB (0.47) | NOTUMKMT2ATDP1DRD2DRD3 | |
| SCHEMBL10755793 | 0.81 | NOTUM (0.51) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL7465147 | 0.80 | NOTUM (0.47) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL6198012 | 0.80 | MEN1 (0.47) | NOTUMGAAKMT2AALDH1A1MEN1 | |
| SCHEMBL9954152 | 0.79 | HPGD (0.49) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL10795075 | 0.79 | NOTUM (0.46) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL28534576 | 0.79 | NOTUM (0.58) | NOTUMHPGDCASP3CASP6SENP8 | |
| SCHEMBL13495339 | 0.78 | RNASEH1 (0.56) | HPGDCASP3CASP6SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12553028-B2 | Method to generate induced oligodendrocyte-lineage cells and treatment using such cells | ACADEMIA SINICA (TW) | 2026-02-17 | — | — | US | disclosed |
| US-20240316014-A1 | METHOD FOR TREATING DEMYELINATING CONDITIONS | ACADEMIA SINICA (TW) | 2024-09-26 | — | — | US | disclosed |
| US-10815222-B2 | Compounds for use in the treatment of kinetoplastid infection | C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2020-10-27 | — | — | US | disclosed |
| US-10751380-B2 | Compound and method for treating spasms, inflammation and pain | MEDEXY LLC | 2020-08-25 | — | — | US | disclosed |
| US-20200095232-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING (IT) | 2020-03-26 | — | — | US | disclosed |
| EP-3558980-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening (IT) | 2019-10-30 | — | — | EP | disclosed |
| US-20180193399-A1 | COMPOUND AND METHOD FOR TREATING SPASMS, INFLAMMATION AND PAIN | MEDEXY LLC | 2018-07-12 | — | — | US | disclosed |
| WO-2018115275-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | IRBM SCIENCE PARK S.P.A. (IT) | 2018-06-28 | — | — | WO | disclosed |
| US-20180169172-A1 | COMPOUND AND METHOD FOR REDUCING APPETITE, FATIGUE AND PAIN | KARIMAN ALEXANDER (US) | 2018-06-21 | — | — | US | disclosed |
| US-8524898-B2 | Proton acceptor iminium/carbocation-type coupling agents | LUXEMBOURG BIO TECHNOLOGIES LTD. (IL) | 2013-09-03 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |
| EP-0580502-B1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR (FR) | 1998-09-02 | — | — | EP | disclosed |
| EP-0646115-A1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-04-05 | — | — | EP | disclosed |
| US-5382593-A | Antioxidants or anticoagulants | ADIR ET COMPAGNIE (FR) | 1995-01-17 | — | — | US | disclosed |
| EP-0580502-A1 | 3-(Hydroxybenzylidenyl)-indoline-2-ones and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017475-A1 | HETEROCYCLIC-CYCLIC AMINE DERIVATIVES | PFIZER INC. (US) | 1992-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12553028-B2 | Method to generate induced oligodendrocyte-lineage cells and treatment using such cells | HDAC4, HDAC9, MYT1 | NOTUM 4049/4885HPGD 1049/4885CASP3 1052/4885 |
| US-10815222-B2 | Compounds for use in the treatment of kinetoplastid infection | NISCH, TK2, FDPS | NOTUM 2310/4885HPGD 115/4885CASP3 708/4885 |
| US-20200095232-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF KINETOPLASTID INFECTION | NISCH, TK2, FDPS | NOTUM 2310/4885HPGD 115/4885CASP3 708/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | NOTUM 4145/4885HPGD 3379/4885CASP3 1035/4885 |
| US-20240316014-A1 | METHOD FOR TREATING DEMYELINATING CONDITIONS | CDK5, PMP22, MYT1 | NOTUM 2285/4885HPGD 2017/4885CASP3 2469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.