SCHEMBL5470148

SCHEMBL5470148

Cc1ccc(S(=O)(=O)N[C@@H](CCCCN)C(=O)[CH]Cl)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 5/20 0.57
MMP9 P14780 3/20 0.57
PLAU P00749 6/20 0.47
HPN P05981 6/20 0.47
TDP1 Q9NUW8 1/20 0.44
SLC1A3 P43003 1/20 0.44
SLC1A2 P43004 1/20 0.44
SLC1A1 P43005 1/20 0.44
CA2 P00918 2/20 0.44
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
ITGB3 P05106 1/20 0.44
ITGA2B P08514 1/20 0.44
MMP13 P45452 3/20 0.42
MMP1 P03956 2/20 0.42
CA1 P00915 1/20 0.42
MMP8 P22894 1/20 0.42
CA14 Q9ULX7 1/20 0.42
MMP3 P08254 2/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5470145 1.00 MMP2 (0.57) MMP2MMP9PLAUHPNTDP1
SCHEMBL28509074 0.87 MMP2 (0.60) MMP2MMP9PLAUHPNTDP1
SCHEMBL10585071 0.86 MMP9 (0.76) MMP2MMP9PLAUHPNTDP1
SCHEMBL8001084 0.86 MMP9 (0.76) MMP2MMP9PLAUHPNTDP1
SCHEMBL457772 0.86 MMP9 (0.76) MMP2MMP9PLAUHPNTDP1
SCHEMBL6893970 0.86 MMP2 (0.61) MMP2MMP9PLAUHPNTDP1
Formaldehyde SCHEMBL28396754 0.85 MMP2 (0.57) MMP2MMP9PLAUHPNTDP1
SCHEMBL8322406 0.85 MMP9 (0.71) MMP2MMP9PLAUHPNTDP1
SCHEMBL200245 0.85 MMP2 (0.57) MMP2MMP9PLAUHPNTDP1
SCHEMBL200247 0.85 MMP2 (0.57) MMP2MMP9PLAUHPNTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0158981-B1 NEW PROTEASE AND PROCESS FOR PRODUCTION AND USE THEREOF SUNTORY LIMITED (JP) 1991-07-10 EP claimed
EP-0230670-B1 NOVEL HOST E. COLI AND USE THEREOF SUNTORY LIMITED (JP) 1991-07-03 EP claimed
US-20070269832-A1 Novel affinity labels IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2007-11-22 US disclosed
US-20060148023-A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2006-07-06 US disclosed
US-20050136492-A1 Affinity labeling of enzymes for detection of enzyme activity level in living cells IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2005-06-23 US disclosed
WO-2003104394-A2 NUCLEIC ACID MOLECULES ENCODING A TRANSMEMBRANE SERINE PROTEASE 12, THE ENCODED POLYPEPTIDES AND METHODS BASED THEREON DENDREON SAN DIEGO LLC (US) 2003-12-18 WO disclosed
WO-2003059877-A2 NOVEL AFFINITY LABELS IMMUNOCHEMISTRY TECHNOLOGIES, LLC (US) 2003-07-24 WO disclosed
WO-2003060466-A2 AFFINITY LABELING OF SERINE PROTEASES FOR SIMULTANEOUS DETECTION OF MULTIPLE SERINE PROTEASE ACTIVITY LEVELS IMMUNOCHEMISTRY TECHNOLOGIES, LLC (US) 2003-07-24 WO disclosed
WO-2003058194-A2 AFFINITY LABELING OF ENZYMES FOR DETECTION OF ENZYME ACTIVITY LEVEL IN LIVING CELLS IMMUNOCHEMISTRY TECHNOLOGIES, LLC (US) 2003-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070269832-A1 Novel affinity labels ANPEP, SLC7A1, DNPEP MMP2 50/4885MMP9 421/4885PLAU 442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.