Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR3A | P46098 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700508 | 0.89 | HTR2C (0.47) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4703073 | 0.88 | HTR2C (0.57) | HTR1AHTR3AHTR2CSIGMAR1KHK | |
| SCHEMBL4698461 | 0.88 | HTR2C (0.46) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4702831 | 0.86 | HTR1A (0.49) | HTR1AHTR3AHTR2CSIGMAR1KHK | |
| SCHEMBL4698232 | 0.86 | HTR2C (0.56) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4698848 | 0.86 | HTR1A (0.49) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4698974 | 0.86 | HTR2C (0.56) | HTR2CSIGMAR1KHKMAPTKDM4E | |
| SCHEMBL4698584 | 0.85 | HTR1A (0.52) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4699170 | 0.85 | HTR2C (0.44) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL546580 | 0.85 | HTR1A (0.52) | HTR1AHTR3ACYP1A2CYP3A4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | claimed |
| EP-1749818-B1 | Phenyl-piperidine derivatives as serotonin reuptake inhibitors | LUNDBECK & CO AS H (DK) | 2009-09-02 | — | — | EP | claimed |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2007-03-15 | — | — | US | claimed |
| EP-1749818-A2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. Lundbeck A/S (DK) | 2007-02-07 | — | — | EP | claimed |
| US-7138407-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-11-21 | — | — | US | claimed |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-20 | — | — | US | claimed |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2005-01-20 | — | — | US | claimed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | claimed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | claimed |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2021-09-09 | — | — | US | disclosed |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2020-11-24 | — | — | US | disclosed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | disclosed |
| US-9708280-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2017-07-18 | — | — | US | disclosed |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2016-05-19 | — | — | US | disclosed |
| US-7138407-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-11-21 | — | — | US | disclosed |
| US-20060089368-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-27 | — | — | US | disclosed |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-20 | — | — | US | disclosed |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2005-01-20 | — | — | US | disclosed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089368-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.