Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 2/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | GNRHR | P30968 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14597072 | 0.92 | TSHR (0.48) | APOBEC3AAPOBEC3GNPC1RAB9APKM | |
| Trifluoroacetic Acid SCHEMBL5469149 | 0.84 | RAB9A (0.53) | RAB9APKMTSHRKDM4EHTT | |
| SCHEMBL5469944 | 0.77 | MEN1 (0.54) | GNRHRTSHRKDM4EHTTKMT2A | |
| SCHEMBL5474130 | 0.77 | PKM (0.43) | APOBEC3AAPOBEC3GNPC1RAB9APKM | |
| Trifluoroacetic Acid SCHEMBL5472885 | 0.77 | KDM4E (0.39) | NPC1GNRHRKDM4EHTTKMT2A | |
| Trifluoroacetic Acid SCHEMBL5461737 | 0.76 | GNRHR (0.40) | NPC1PKMGNRHRKDM4EHTT | |
| Trifluoroacetic Acid SCHEMBL5461048 | 0.75 | GNRHR (0.44) | PKMGNRHRKDM4EHTTTP53 | |
| SCHEMBL5461553 | 0.75 | GNRHR (0.51) | GNRHRKDM4EHTTKMT2ATP53 | |
| SCHEMBL5470082 | 0.73 | RXFP1 (0.53) | PKMGNRHRTSHRKDM4EHTT | |
| Trifluoroacetic Acid SCHEMBL5472760 | 0.73 | MAPT (0.42) | TSHRKDM4EKMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | US | disclosed |
| EP-1657238-A1 | FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010537-A1 | Fused pyramidine derivative and use thereof | NR5A1, GNRHR, RXFP3 | APOBEC3A 2160/4885APOBEC3G 3648/4885NPC1 4313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.