Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.42 |
| ▸ | PDE5A | O76074 | 4/20 | 0.39 |
| ▸ | PDE1A | P54750 | 4/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470133 | 0.81 | CHEK1 (0.57) | ADORA1CHEK1PDE5APDE1APDE1B | |
| SCHEMBL5795592 | 0.79 | ADORA1 (0.46) | ADORA1CHEK1PDE5APDE1APDE1B | |
| SCHEMBL5480686 | 0.76 | CHEK1 (0.64) | ADORA1CHEK1 | |
| SCHEMBL5465647 | 0.76 | CHEK1 (0.64) | CHEK1 | |
| SCHEMBL5473192 | 0.75 | CHEK1 (0.56) | ADORA1CHEK1PDE5APDE1APDE1B | |
| SCHEMBL5469935 | 0.74 | CHEK1 (0.54) | CHEK1KDR | |
| SCHEMBL11069723 | 0.71 | LMNA (0.44) | ADORA1CHEK1PDE5APDE1APDE1B | |
| SCHEMBL23177017 | 0.70 | ADORA2A (0.44) | ADORA1DYRK1BLIMK1DYRK1ACLK4 | |
| SCHEMBL1602164 | 0.70 | CHEK1 (0.54) | ADORA1CHEK1PDE5APDE1APDE1B | |
| SCHEMBL5470155 | 0.70 | CHEK1 (0.70) | CHEK1KDRGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | claimed |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | TP53, BRCA1, KLK3 | ADORA1 4216/4885CHEK1 13/4885PDE5A 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.