Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | PDE1A | P54750 | 3/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469934 | 0.83 | CHEK1 (0.39) | ADORA1CHEK1MAP3K7JAK2KDR | |
| SCHEMBL5475725 | 0.82 | CHEK1 (0.45) | ADORA1CHEK1MAP3K7JAK2KDR | |
| SCHEMBL5475307 | 0.79 | ADORA1 (0.45) | ADORA1CHEK1KDRPDE5APDE1A | |
| SCHEMBL5483335 | 0.79 | KDM4E (0.44) | CHEK1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL5478073 | 0.78 | CHEK1 (0.63) | CHEK1MAP3K7JAK2KDRPDE1A | |
| SCHEMBL5469037 | 0.77 | CHEK1 (0.66) | CHEK1MAP3K7JAK2KDR | |
| SCHEMBL5822250 | 0.71 | ADORA1 (0.47) | ADORA1CHEK1 | |
| SCHEMBL11069723 | 0.69 | LMNA (0.44) | ADORA1CHEK1KDRPDE5APDE1A | |
| SCHEMBL13824909 | 0.69 | LTK (0.50) | CHEK1MAP3K7JAK2KDRPDE5A | |
| SCHEMBL1602164 | 0.68 | CHEK1 (0.54) | ADORA1CHEK1PDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006520397-A | — | — | 2006-09-07 | — | — | JP | claimed |
| EP-1613625-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | claimed |
| WO-2004081008-A1 | NOVEL FUSED TRIAZOLONES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |