Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6747193 | 0.81 | TP53 (0.43) | TP53KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL10379466 | 0.80 | MAP3K8 (0.50) | TP53KDM4ENOTUMMAPTHSD17B10 | |
| SCHEMBL5475078 | 0.78 | — | — | |
| SCHEMBL6291529 | 0.77 | — | — | |
| SCHEMBL2118555 | 0.75 | PAK1 (0.48) | TP53NOTUMHSD17B10HPGDNPSR1 | |
| SCHEMBL4678313 | 0.75 | TP53 (0.41) | TP53KDM4ENOTUMMAPTHSD17B10 | |
| SCHEMBL9177428 | 0.75 | TP53 (0.46) | TP53KDM4ENOTUMMAPTHSD17B10 | |
| SCHEMBL2115552 | 0.75 | PAK1 (0.40) | TP53NOTUMMAPTHSD17B10HPGD | |
| SCHEMBL14185048 | 0.74 | SLC6A5 (0.44) | TP53KDM4ENOTUMMAPTMEN1 | |
| SCHEMBL735449 | 0.74 | NOTUM (0.60) | NOTUMMEN1KMT2AHPGDRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | claimed |
| WO-2005120577-A2 | DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-12-22 | — | — | WO | claimed |
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | disclosed |
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | disclosed |
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | disclosed |
| WO-2005120577-A2 | DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | DHFR, FAU, MYD88 | TP53 62/4885KDM4E 896/4885NOTUM 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.