Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 14/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.31 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethyl Hydrogen Phosphate SCHEMBL5476334 | 0.75 | L3MBTL1 (0.39) | DDB1CRBNIKZF3 | |
| SCHEMBL2919642 | 0.75 | CRBN (0.50) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL24421112 | 0.71 | CRBN (0.55) | DDB1CRBNIKZF3 | |
| SCHEMBL19359168 | 0.68 | DDB1 (0.56) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL21615149 | 0.68 | DDB1 (0.57) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL22143923 | 0.67 | DDB1 (0.49) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL4934289 | 0.67 | DDB1 (0.54) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL12041901 | 0.67 | DDB1 (0.54) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL21402688 | 0.67 | CRBN (0.36) | DDB1CRBNTNFIL1BTBXA2R | |
| SCHEMBL31623343 | 0.67 | CRBN (0.36) | DDB1CRBNTNFIL1BTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | claimed |
| WO-2005120577-A2 | DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-12-22 | — | — | WO | claimed |
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-12-20 | — | — | US | disclosed |
| WO-2005120577-A2 | DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293517-A1 | Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety | DHFR, FAU, MYD88 | DDB1 740/4885CRBN 931/4885TNF 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.