Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547692 | 0.82 | HDAC2 (0.57) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL28855893 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HDAC2HDAC8HDAC3HDAC6 | |
| SCHEMBL10048315 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TP53NPY1RNPY2RTSHR | |
| SCHEMBL8200430 | 0.78 | HDAC2 (0.77) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL3067050 | 0.77 | HPGD (0.66) | ALDH1A1HDAC2HDAC8HDAC3HDAC6 | |
| SCHEMBL15741881 | 0.77 | ALDH1A1 (0.97) | ALDH1A1HDAC2HDAC8HDAC3HDAC6 | |
| SCHEMBL8296171 | 0.77 | HDAC2 (0.64) | ALDH1A1HDAC2HDAC8HDAC3HDAC6 | |
| SCHEMBL27688343 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TP53NPY1RNPY2RTSHR | |
| SCHEMBL14264185 | 0.77 | HDAC2 (0.52) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL11514409 | 0.76 | CYP1A2 (0.52) | ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| EP-2086950-A2 | HISTONE DEACETYLASE INHIBITORS | Queen Mary and Westfield College (GB) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC4 | ALDH1A1 2757/4885HDAC2 4/4885HDAC8 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.