Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 11/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.56 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200430 | 0.86 | HDAC2 (0.77) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL14264185 | 0.85 | HDAC2 (0.52) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8363039 | 0.84 | HDAC2 (0.68) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL547643 | 0.82 | ALDH1A1 (0.61) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8296171 | 0.79 | HDAC2 (0.64) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL14254913 | 0.79 | HDAC1 (0.61) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL14254988 | 0.79 | HDAC1 (0.61) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL1064861 | 0.78 | HDAC4 (0.77) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL312344 | 0.78 | HDAC4 (0.77) | HDAC2HDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL8145665 | 0.77 | HDAC2 (0.62) | HDAC2HDAC8HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| EP-2086950-A2 | HISTONE DEACETYLASE INHIBITORS | Queen Mary and Westfield College (GB) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC4 | HDAC2 4/4885HDAC8 6/4885HDAC6 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.