Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.82 |
| ▸ | HTR3A | P46098 | 20/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.78 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.68 |
| ▸ | HRH2 | P25021 | 2/20 | 0.68 |
| ▸ | HTR1B | P28222 | 2/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR2C | P28335 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.68 |
| ▸ | HTR7 | P34969 | 2/20 | 0.68 |
| ▸ | HRH1 | P35367 | 2/20 | 0.68 |
| ▸ | HTR5A | P47898 | 2/20 | 0.68 |
| ▸ | HTR6 | P50406 | 2/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27894544 | 0.98 | HTR1A (0.80) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL28043137 | 0.97 | HTR1A (0.78) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27976827 | 0.90 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL546684 | 0.88 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| Tert-Butyl Formate SCHEMBL28112659 | 0.87 | HTR1A (0.63) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL20360588 | 0.87 | HTR1A (0.97) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL547714 | 0.87 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL546479 | 0.85 | HTR1A (0.90) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17777981 | 0.84 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14734867 | 0.84 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113125586-B | Detection method of 1- [2- (2, 4-dimethyl-thiophenyl) -phenyl ] piperazine and isomer thereof | 成都百裕制药股份有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-113125586-A | Detection method of 1- [2- (2, 4-dimethyl-thiophenyl) -phenyl ] piperazine and isomer thereof | 成都百裕制药股份有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-105254590-B | Vortioxetine hydrobromate crystal form and its preparation method and application | 江苏豪森药业集团有限公司 | 2019-09-03 | — | — | CN | claimed |
| CN-106316986-B | A kind of preparation method of 1- [2- (2,4- dimethylphenylsulfanyl) phenyl] piperazine hydrobromide alpha type crystal | 成都弘达药业有限公司 | 2019-02-05 | — | — | CN | claimed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | claimed |
| CN-107954947-A | Vortioxetine hydrobromate crystal form C and preparation method thereof | 北京莱瑞森医药科技有限公司 | 2018-04-24 | — | — | CN | claimed |
| CN-104119298-B | Hydrobromic acid Wo Saiting or hydrobromic acid are fertile for Xi Ting | 北京蓝贝望生物医药科技股份有限公司 | 2016-08-24 | — | — | CN | claimed |
| CN-104119299-B | The Wo Saiting or the fertile hydrobromate for Xi Ting | 北京蓝贝望生物医药科技股份有限公司 | 2016-08-17 | — | — | CN | claimed |
| CN-105254590-A | New crystal form of vortioxetine hydrobromide, preparation method and uses thereof | JIANGSU HANSOH PHARMACEUTICAL | 2016-01-20 | — | — | CN | claimed |
| CN-104974110-A | New crystal form of 1-[2-(2,4-dimethylphenylsulfenyl)phenyl]piperazine hydrobromide, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-10-14 | — | — | CN | claimed |
| CN-102317272-B | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine | LUNDBECK & CO AS H | 2014-11-12 | — | — | CN | claimed |
| CN-102317272-A | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine | LUNDBECK & CO AS H | 2012-01-11 | — | — | CN | claimed |
| EP-1436271-B1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | LUNDBECK & CO AS H (DK) | 2008-02-20 | — | — | EP | claimed |
| CN-1319958-C | Phenyl piperazine derivatives as serotonin reuptake inhibitors | LUNDBECK & CO AS H (DK) | 2007-06-06 | — | — | CN | claimed |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2007-03-15 | — | — | US | claimed |
| US-7144884-B2 | E.g., 4-[2-(4-Methylphenoxy)- or 4-[2-(4-Methylphenylsulfanyl)-phenyl]-3,6-dihydro-2H-pyridine or piperazine or the hydrochloride or oxalate; treating depression, anxiety disorder, and obsessive compulsive disorder. | H. LUNDBECK A/S (DK) | 2006-12-05 | — | — | US | claimed |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2005-01-20 | — | — | US | claimed |
| CN-1561336-A | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | LUNDBECK & CO AS H (DK) | 2005-01-05 | — | — | CN | claimed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | claimed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.