Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 11/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296171 | 0.99 | HDAC2 (0.64) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL8296679 | 0.86 | HDAC8 (0.47) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL8243069 | 0.85 | ALDH1A1 (0.53) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL5524304 | 0.84 | ALDH1A1 (0.67) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL6256778 | 0.84 | ALDH1A1 (0.52) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL8296136 | 0.84 | LMNA (0.57) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL13175364 | 0.83 | LMNA (0.60) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL5955806 | 0.82 | MEN1 (0.60) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL11394141 | 0.82 | ALDH1A1 (0.59) | HDAC2HDAC8HDAC3HDAC6HDAC1 | |
| SCHEMBL8296132 | 0.80 | MMP8 (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103165-A2 | ANTI-KIT ANTIBODIES AND USES THEREOF | KOLLTAN PHARMACEUTICALS, INC. (US) | 2012-08-02 | — | — | WO | disclosed |
| EP-2266552-A2 | Methods of inducing terminal differentiation | Merck HDAC Research, LLC (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-2201947-A2 | Use of SAHA for treating mesothelioma | Merck HDAC Research, LLC (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-2082737-A2 | Methods of inducing terminal differentiation | Merck HDAC Research, LLC (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008097654-A1 | METHODS OF USING SAHA FOR TREATING HIV INFECTION | MERCK & CO., INC. (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2007056135-A1 | METHOD OF TREATING CANCERS WITH SAHA AND PEMETREXED | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056244-A2 | METHODS OF USING SAHA AND ERLOTINIB FOR TREATING CANCER | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056162-A2 | METHODS OF TREATING CANCERS WITH SAHA, CARBOPLATIN, AND PACLITAXEL AND OTHER COMBINATION THERAPIES | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056243-A2 | METHODS OF TREATING CANCERS WITH SAHA AND FLUOROURACIL AND OTHER COMBINATION THERAPIES | MERCK & CO. INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056232-A2 | METHODS OF USING SAHA AND BORTEZOMIB FOR TREATING CANCER | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007022408-A2 | COMBINATION METHODS OF SAHA AND TARGRETIN FOR TREATING CANCER | MERCK & CO., INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2005023179-A2 | COMBINATION METHODS OF TREATING CANCER | ATON PHARMA, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| WO-2003075839-A2 | METHODS OF INDUCING TERMINAL DIFFERENTIATION | ATON PHARMA, INC. (US) | 2003-09-18 | — | — | WO | disclosed |