Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629973 | 1.00 | NPSR1 (0.55) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL28575888 | 0.94 | NPSR1 (0.57) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL17131834 | 0.94 | NPSR1 (0.61) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL629972 | 0.94 | NPSR1 (0.61) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL6673813 | 0.92 | NPSR1 (0.63) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL10596450 | 0.87 | NPSR1 (0.53) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL1769746 | 0.87 | NPSR1 (0.53) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL8854160 | 0.86 | RAB9A (0.61) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL18240156 | 0.85 | NPC1 (0.54) | NPSR1ALDH1A1NPC1POLBHTT | |
| SCHEMBL18240146 | 0.85 | NPC1 (0.54) | NPSR1ALDH1A1NPC1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110577-B2 | Histone deacetylase inhibitors | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-02-07 | — | — | US | disclosed |
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-06-24 | — | — | US | disclosed |
| EP-2086950-A2 | HISTONE DEACETYLASE INHIBITORS | Queen Mary and Westfield College (GB) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008047138-A2 | HISTONE DEACETYLASE INHIBITORS | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160392-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC4 | NPSR1 519/4885ALDH1A1 2757/4885NPC1 2144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.