SCHEMBL5477563

SCHEMBL5477563

CC1=Cc2c(-c3cc(C(C)(C)C)cc(C(C)(C)C)c3)cccc2C1[Si](C)(C)Cl

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RXRB P28702 2/20 0.31
RXRA P19793 1/20 0.31
PTAFR P25105 1/20 0.31
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29767551 0.90
SCHEMBL20972416 0.90
SCHEMBL7035204 0.90 RXRB (0.32) RXRBRXRAKIF11
SCHEMBL31099225 0.90 RXRB (0.32) RXRBRXRAKIF11
SCHEMBL31099220 0.90 RXRB (0.32) RXRBRXRAKIF11
SCHEMBL2388282 0.88 NPC1 (0.35) PTAFRKIF11
SCHEMBL1454464 0.85 PTAFR (0.33) PTAFR
SCHEMBL15809414 0.85 KDM4E (0.33)
SCHEMBL16394493 0.84
SCHEMBL20165813 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3022235-B1 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC (US) 2020-04-08 EP disclosed
US-9944665-B2 Bridged bis(indenyl) transitional metal complexes, production, and use thereof EXXONMOBIL CHEMICAL PATENTS INC. (US) 2018-04-17 US disclosed
EP-3022238-B1 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC (US) 2017-09-20 EP disclosed
US-9745390-B2 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-08-29 US disclosed
US-9676882-B2 Processes using staged hydrogen addition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-06-13 US disclosed
US-9464145-B2 Metallocenes and catalyst compositions derived therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-10-11 US disclosed
EP-3022235-A1 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM ExxonMobil Chemical Patents Inc. (US) 2016-05-25 EP disclosed
US-20160137763-A1 Processes Using Staged Hydrogen Addition EXXONMOBIL CHEMICAL PATENTS INC. 2016-05-19 US disclosed
US-20160130374-A1 Metallocenes and Catalyst Compositions Derived Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2016-05-12 US disclosed
US-9279024-B2 Processes using staged hydrogen addition EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-03-08 US disclosed
WO-2015065676-A1 PROCESSES USING STAGED HYDROGEN ADDITION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-05-07 WO disclosed
US-20150119537-A1 Processes Using Staged Hydrogen Addition EXXONMOBIL CHEMICAL PATENTS INC. 2015-04-30 US disclosed
WO-2015009471-A1 METALLOCENES AND CATALYST COMPOSITIONS DERIVED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-01-22 WO disclosed
US-20150025205-A1 Metallocenes and Catalyst Compositions Derived Tehrefrom EXXONMOBIL CHEMICAL PATENTS INC. 2015-01-22 US disclosed
US-20150025208-A1 Metallocenes and Catalyst Compositions Derived Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2015-01-22 US disclosed
US-7241903-B2 Metallocenes, use in catalyst system for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2007-07-10 US disclosed
EP-1397371-B1 METALLOCENES AND THEIR USE IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL POLYOLEFINE GMBH (DE) 2006-03-22 EP disclosed
US-20040171855-A1 Metallocenes, use in catalyst system for producing olefin polymers EQUISTAR CHEMICALS, LP 2004-09-02 US disclosed
EP-1397371-A1 METALLOCENES AND THEIR USE IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS Basell Polyolefine GmbH (DE) 2004-03-17 EP disclosed
WO-2003000706-A1 METALLOCENES, USE IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL POLYOLEFINE GMBH (DE) 2003-01-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040171855-A1 Metallocenes, use in catalyst system for producing olefin polymers H1-4, H1-0, H1-10 RXRB 1131/4885RXRA 848/4885PTAFR 3013/4885
US-20150025205-A1 Metallocenes and Catalyst Compositions Derived Tehrefrom TERF2, TERT, TERF2IP RXRB 3327/4885RXRA 2959/4885PTAFR 1207/4885
US-20150025208-A1 Metallocenes and Catalyst Compositions Derived Therefrom CARM1, B2M, TIMM10 RXRB 2633/4885RXRA 1419/4885PTAFR 1601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.