Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 6/20 | 0.38 |
| ▸ | GABRD | O14764 | 6/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488835 | 0.85 | NPC1 (0.36) | DGAT1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5485859 | 0.81 | NPC1 (0.36) | DGAT1MAPTTSHRHSD17B10NPC1 | |
| SCHEMBL27094264 | 0.81 | ALDH1A1 (0.38) | DGAT1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2960376 | 0.79 | CA12 (0.40) | ALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL14255842 | 0.79 | ALDH1A1 (0.44) | DGAT1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL20168404 | 0.79 | NOTUM (0.43) | NOTUMDGAT1ALDH1A1MAPTKDM4E | |
| SCHEMBL3528543 | 0.77 | MAPT (0.43) | DGAT1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL3023087 | 0.77 | DGAT1 (0.38) | DGAT1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL16100174 | 0.77 | DGAT1 (0.38) | DGAT1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7431910 | 0.76 | DGAT1 (0.49) | DGAT1ALDH1A1KDM4EHPGDGABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | GRM5, GRIK5, GRM2 | NOTUM 2476/4885DGAT1 1498/4885ALDH1A1 4603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.