Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.32 |
| ▸ | PNP | P00491 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HBB | P68871 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488835 | 0.86 | NPC1 (0.36) | NPC1MAPTBRD4CREBBPDGAT1 | |
| SCHEMBL5478263 | 0.81 | NOTUM (0.40) | NPC1MAPTDGAT1TSHRHSD17B10 | |
| SCHEMBL2963054 | 0.79 | NPC1 (0.42) | NPC1MAPTDGAT1KLKB1PRMT5 | |
| SCHEMBL28966690 | 0.76 | DGAT1 (0.35) | NPC1BRD4CREBBPDGAT1PNP | |
| SCHEMBL2965634 | 0.71 | NPC1 (0.39) | NPC1MAPTDGAT1RECQLBLM | |
| SCHEMBL24724721 | 0.69 | NPC1 (0.40) | NPC1MAPTCREBBPDGAT1HSD17B10 | |
| SCHEMBL3521311 | 0.69 | SMN1; SMN2 (0.40) | NPC1BRD4CREBBPDGAT1 | |
| SCHEMBL24724723 | 0.69 | NPC1 (0.41) | NPC1BRD4CREBBPDGAT1KLKB1 | |
| SCHEMBL24724722 | 0.69 | NPC1 (0.41) | NPC1DGAT1KMT2AKLKB1 | |
| SCHEMBL10117725 | 0.68 | ALDH1A1 (0.38) | NPC1MAPTBRD4DGAT1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | GRM5, GRIK5, GRM2 | NPC1 934/4885MAPT 711/4885BRD4 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.