Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | IAPP | P10997 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478305 | 1.00 | GLA (0.52) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL23289048 | 0.84 | ALDH1A1 (0.42) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL2059374 | 0.83 | HCAR2 (0.50) | ALDH1A1KMT2AKDM4ESMN1; SMN2GAA | |
| SCHEMBL2059378 | 0.83 | HCAR2 (0.50) | ALDH1A1KMT2AKDM4ESMN1; SMN2GAA | |
| SCHEMBL6049311 | 0.81 | GLA (0.45) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL30560968 | 0.81 | DRD2 (0.40) | LMNAALDH1A1KDM4EPTGS1SMN1; SMN2 | |
| SCHEMBL6049312 | 0.81 | GLA (0.45) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL5336688 | 0.78 | ABCB1 (0.49) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL5336696 | 0.78 | ABCB1 (0.49) | GLATDP1IAPPMAPTLMNA | |
| SCHEMBL3360246 | 0.78 | IAPP (0.53) | IAPPMAPTLMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-4826864-A | Substituted imidazole derivatives useful as antihypertensive or antithromtic agent or divretic | FARMOS GROUP LTD. (FI) | 1989-05-02 | — | — | US | disclosed |
| US-4639464-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1987-01-27 | — | — | US | disclosed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | disclosed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | disclosed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | GLA 2558/4885TDP1 3303/4885IAPP 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.