SCHEMBL5478772

SCHEMBL5478772

CNC(=O)Nc1[c]nccc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
RECQL P46063 1/20 0.46
POLB P06746 3/20 0.44
TDP1 Q9NUW8 1/20 0.44
GCK P35557 3/20 0.37
MKNK1 Q9BUB5 1/20 0.35
MKNK2 Q9HBH9 1/20 0.35
KMT2A Q03164 1/20 0.34
PLK1 P53350 1/20 0.34
KDM4E B2RXH2 1/20 0.33
HPGD P15428 1/20 0.33
LMNA P02545 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
HTT P42858 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1906809 0.81 HSD17B10 (0.41) ALDH1A1SMN1; SMN2POLBTDP1KMT2A
SCHEMBL3428561 0.81 NPC1 (0.44) SMN1; SMN2NPC1RAB9A
SCHEMBL1903812 0.79 SMN1; SMN2 (0.57) SMN1; SMN2KMT2ANPC1RAB9AHTT
SCHEMBL3430680 0.79 SMN1; SMN2 (0.39) ALDH1A1SMN1; SMN2POLBKMT2AKDM4E
SCHEMBL5481558 0.78 CDK2 (0.35) SMN1; SMN2KMT2ANPC1RAB9AHTT
SCHEMBL5472894 0.78 L3MBTL1 (0.36) SMN1; SMN2KMT2ALMNANPC1RAB9A
SCHEMBL5481218 0.78 GAA (0.36) ALDH1A1RECQLKMT2AKDM4ELMNA
SCHEMBL5481198 0.77 TSHR (0.40) KDM4EHTT
SCHEMBL12468731 0.77 SMN1; SMN2 (0.41) ALDH1A1SMN1; SMN2POLBKMT2AKDM4E
SCHEMBL3430577 0.77 SMN1; SMN2 (0.55) ALDH1A1SMN1; SMN2POLBKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD ALDH1A1 620/4885SMN1; SMN2 4822/4885RECQL 1789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.