SCHEMBL5481218

SCHEMBL5481218

NC(=O)Nc1[c]nccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.36
MAPT P10636 1/20 0.36
GFER P55789 1/20 0.36
PEPD P12955 1/20 0.35
KDM4E B2RXH2 1/20 0.35
RECQL P46063 1/20 0.35
ALDH1A1 P00352 2/20 0.34
NPC1 O15118 1/20 0.34
NR3C2 P08235 4/20 0.34
CYP3A4 P08684 1/20 0.34
IKBKB O14920 1/20 0.33
F7 P08709 1/20 0.33
F3 P13726 1/20 0.33
SARM1 Q6SZW1 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
SIRT6 Q8N6T7 1/20 0.33
SIRT1 Q96EB6 1/20 0.33
SIRT3 Q9NTG7 1/20 0.33
SIRT5 Q9NXA8 1/20 0.33
SIRT4 Q9Y6E7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1906809 0.81 HSD17B10 (0.41) GAAMAPTKDM4EALDH1A1NPC1
SCHEMBL12468924 0.78 TGM2 (0.47) LMNA
SCHEMBL3430680 0.78 SMN1; SMN2 (0.39) GAAMAPTKDM4EALDH1A1NPC1
SCHEMBL5478772 0.78 ALDH1A1 (0.46) MAPTKDM4ERECQLALDH1A1NPC1
SCHEMBL16935696 0.78 XIAP (0.45)
SCHEMBL8918118 0.77 LMNA (0.34) GAALMNA
SCHEMBL12468731 0.77 SMN1; SMN2 (0.41) GAAMAPTKDM4EALDH1A1NPC1
SCHEMBL5481198 0.77 TSHR (0.40) KDM4E
SCHEMBL4780491 0.77 L3MBTL1 (0.39) GAAMAPTKDM4ENPC1CYP1A2
SCHEMBL1903812 0.75 SMN1; SMN2 (0.57) GAAMAPTNPC1SIRT1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD GAA 842/4885MAPT 3974/4885GFER 1819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.