Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430577 | 0.85 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5472894 | 0.84 | L3MBTL1 (0.36) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5478772 | 0.81 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12468731 | 0.80 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1906809 | 0.78 | HSD17B10 (0.41) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5914583 | 0.77 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2GAAJAK2 | |
| SCHEMBL1903812 | 0.75 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL3430680 | 0.75 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5481218 | 0.74 | GAA (0.36) | NPC1GAA | |
| SCHEMBL1665108 | 0.73 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2GAAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146351-A1 | INDOLYLMETHYL-MORPHOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-12-23 | — | — | WO | disclosed |