SCHEMBL5478808

SCHEMBL5478808

CO[Si](CCCNC(=O)OCc1cc([N+](=O)[O-])c(C)c([N+](=O)[O-])c1)(OC)OC

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
LMNA P02545 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAPT P10636 1/20 0.37
RECQL P46063 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HTT P42858 2/20 0.37
DPP8 Q6V1X1 1/20 0.36
DPP9 Q86TI2 1/20 0.36
EGFR P00533 1/20 0.36
PRMT5 O14744 1/20 0.35
WDR77 Q9BQA1 1/20 0.35
FAAH O00519 1/20 0.35
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
MGLL Q99685 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19895211 0.81 DPP8 (0.53) ALDH1A1L3MBTL1MAPTHTTDPP8
SCHEMBL18295402 0.81 CYP3A4 (0.47) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL18294090 0.80 CYP3A4 (0.40) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL19895213 0.79 PTPN1 (0.46) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL14565609 0.77 MGLL (0.42) ALDH1A1KMT2AL3MBTL1MAPTSMN1; SMN2
SCHEMBL14129489 0.75 ALDH1A1 (0.42) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL19895184 0.71 ALDH1A1 (0.44) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL6537376 0.71 HTT (0.44) LMNAL3MBTL1MAPTSMN1; SMN2HTT
SCHEMBL19450633 0.70 CYP3A4 (0.46) ALDH1A1LMNAMEN1KMT2AL3MBTL1
SCHEMBL141826 0.70 ACHE (0.48) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070059211-A1 TNT sensor containing molecularly imprinted sol gel-derived films THE COLLEGE OF WOOSTER (US) 2007-03-15 US claimed
US-20070059211-A1 TNT sensor containing molecularly imprinted sol gel-derived films THE COLLEGE OF WOOSTER (US) 2007-03-15 US disclosed