Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181884 | 0.88 | CHRNB2 (0.63) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL28534097 | 0.87 | CHRNB2 (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL28528002 | 0.87 | CHRNB2 (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL28531540 | 0.87 | CHRNB2 (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL4599464 | 0.82 | IDO1 (0.45) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL28531048 | 0.80 | EPHX1 (0.47) | SLC6A4CHRNB2CHRNA4TSHRALDH1A1 | |
| SCHEMBL10344292 | 0.79 | TSHR (0.52) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL11100946 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL10431978 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL29277741 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873293-B1 | IMPROVED PROCESS FOR THE PREPARATION OF ALKYL OR ARYL ALDEHYDE INTERMEDIATES | ABBOTT LAB (US) | 2001-07-25 | — | — | EP | claimed |
| EP-0873293-A1 | IMPROVED PROCESS FOR THE PREPARATION OF ALKYL OR ARYL ALDEHYDE INTERMEDIATES | Abbott Laboratories (US) | 1998-10-28 | — | — | EP | claimed |
| WO-1997023439-A1 | IMPROVED PROCESS FOR THE PREPARATION OF ALKYL OR ARYL ALDEHYDE INTERMEDIATES | ABBOTT LABORATORIES (US) | 1997-07-03 | — | — | WO | claimed |
| EP-3030555-B1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-30 | — | — | EP | disclosed |
| CN-106349105-B | A kind of preparation method of benzyl cyanide | 河北诚信集团有限公司 | 2018-11-27 | — | — | CN | disclosed |
| EP-2470512-B1 | AROMATASE INHIBITOR | ESTRYX PHARMA LTD (GB) | 2018-05-02 | — | — | EP | disclosed |
| CN-104530047-B | Ketone quaternary ammonium salt of iron dung rice 6 and preparation method and application | 西北农林科技大学 | 2017-11-10 | — | — | CN | disclosed |
| CN-106349105-A | Preparation method of substituted benzyl cyanide | 河北诚信有限责任公司 | 2017-01-25 | — | — | CN | disclosed |
| EP-3030555-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| CN-102596919-B | Aromatase inhibitor | STRIX LTD. (GB) | 2015-11-25 | — | — | CN | disclosed |
| US-9096548-B2 | Pyrazine amide compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-08-04 | — | — | US | disclosed |
| US-5401851-A | Preparation of proline derivatives | ELI LILLY AND COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| CN-1098714-A | The 1H-indole-3-acetic acid hydrazide spla 2 inhibitors | LILLY CO ELI (US) | 1995-02-15 | — | — | CN | disclosed |
| CN-1085897-A | Angiotension II antagonists | LILLY CO ELI (US) | 1994-04-27 | — | — | CN | disclosed |
| EP-0573271-A1 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |
| EP-0565317-A1 | (2-(2-hydroxy-2 phenylethylamino)ethoxy) phenyl derivatives, processes and intermediates for their preparation, pharmaceutical compositions containing them and their use as Beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1993-10-13 | — | — | EP | disclosed |
| WO-1993000359-A1 | MODIFIED PEPTIDES TRANSPORTABLE INTO THE CENTRAL NERVOUS SYSTEM | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0183216-B1 | N-(ARALKOXYBENZYL)-4(BENZHYDRYL) PIPERIDINES | G.D. Searle & Co. (US) | 1989-07-19 | — | — | EP | disclosed |
| US-4650874-A | CARDIOVASCULAR AGENTS | G. D. SEARLE & CO. (US) | 1987-03-17 | — | — | US | disclosed |
| EP-0183216-A1 | N-(Aralkoxybenzyl)-4(benzhydryl) piperidines | G.D. Searle & Co. (US) | 1986-06-04 | — | — | EP | disclosed |