Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 4/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626503 | 1.00 | LMNA (0.50) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL31271719 | 1.00 | LMNA (0.50) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL26313182 | 1.00 | LMNA (0.50) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL8108622 | 0.98 | LMNA (0.48) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL3336023 | 0.96 | LMNA (0.46) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL28485613 | 0.96 | KDM5A (0.46) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL25415086 | 0.95 | KDM5A (0.54) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL25319410 | 0.95 | KDM5A (0.54) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL25319358 | 0.95 | KDM5A (0.54) | LMNAALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL25318041 | 0.95 | KDM5A (0.54) | LMNAALDH1A1TSHRHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852506-A2 | Lipophilic derivatives of double-stranded ribonucleic acid | Alnylam Europe AG (DE) | 2007-11-07 | — | — | EP | claimed |
| EP-1587926-B1 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | ALNYLAM EUROPE AG (DE) | 2007-07-18 | — | — | EP | claimed |
| US-20060178324-A1 | Lipophilic derivatives of double-stranded ribonucleic acid | ALNYLAM PHARMACEUTICALS, INC. | 2006-08-10 | — | — | US | claimed |
| EP-1587926-A2 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | Alnylam Europe AG (DE) | 2005-10-26 | — | — | EP | claimed |
| WO-2004065601-A2 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | ALNYLAM EUROPE AG (DE) | 2004-08-05 | — | — | WO | claimed |
| EP-1852506-A2 | Lipophilic derivatives of double-stranded ribonucleic acid | Alnylam Europe AG (DE) | 2007-11-07 | — | — | EP | disclosed |
| EP-1587926-B1 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | ALNYLAM EUROPE AG (DE) | 2007-07-18 | — | — | EP | disclosed |
| EP-1587926-B1 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | ALNYLAM EUROPE AG (DE) | 2007-07-18 | — | — | EP | disclosed |
| US-20060178324-A1 | Lipophilic derivatives of double-stranded ribonucleic acid | ALNYLAM PHARMACEUTICALS, INC. | 2006-08-10 | — | — | US | disclosed |
| EP-1587926-A2 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | Alnylam Europe AG (DE) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004065601-A2 | LIPOPHILIC DERIVATIVES OF DOUBLE-STRANDED RIBONUCLEIC ACID | ALNYLAM EUROPE AG (DE) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178324-A1 | Lipophilic derivatives of double-stranded ribonucleic acid | RNASE1, POLRMT, SNRPE | LMNA 387/4885ALDH1A1 1956/4885TSHR 3089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.