Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975581 | 0.87 | POLB (0.49) | P2RX7GRM1GRM5POLB | |
| SCHEMBL2891520 | 0.86 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL2885844 | 0.84 | TRPV1 (0.41) | HSD11B1 | |
| SCHEMBL2894092 | 0.82 | MEN1 (0.45) | P2RX7 | |
| SCHEMBL5483719 | 0.80 | HTT (0.47) | P2RX7 | |
| SCHEMBL2889480 | 0.73 | P2RX7 (0.42) | P2RX7GRM1GRM5 | |
| SCHEMBL2889100 | 0.73 | MEN1 (0.45) | P2RX7 | |
| SCHEMBL2894048 | 0.73 | RBP4 (0.44) | P2RX7 | |
| SCHEMBL12975589 | 0.73 | POLB (0.56) | GRM1GRM5POLB | |
| SCHEMBL2888999 | 0.73 | GRM5 (0.50) | GRM1GRM5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191389-A1 | Biaryl derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1764362-A1 | BIARYL DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191389-A1 | Biaryl derivatives | GRM1, GRIN1, GRIN2B | P2RX7 1337/4885GRM1 1/4885GRM5 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.